A Review on Therapeutic Activities of Coriandrum sativum L for Rheumatoid Arthritis Remedy

Rheumatoid Arthritis (RA) is an immune-mediated inflammatory condition. It occurs when the immune system attacks the tissue surrounding joints due to the release of specific chemicals and enzymes that start consuming away the cartilage and bones. The ant-arthritis of Coriandrum sativum (CS) has not been summarized before, so this review aims to assess further and explore its efficacy in RA disorders. The online literature search was performed using databases such as ScienceDirect, PubMed, Google Scholar, Wiley Online, Library, Springer, and Taylor& Francis for review. Articles published from January 2010 to January 2024 were composed. Additionally, the molecular docking of the eight selected CS phytochemicals was carried out against the AR protein target (PDB ID: 2AXJ) to support the review. Different parameters such as docking score, oral bioavailability, drug-likeness, absorption, distribution, metabolism, excretion, and toxicity (ADMET) were examined. Docking scores depicted that, anethole, beta-pinene, camphor, and geraniol phytochemicals demonstrated a commendable potential as inhibitors of 2AXJ molecule. The score hierarchy is camphor (-6.9 kcal/mol), beta-pinene (-5.9 kcal/mol), geraniol (-5.3 kcal/mol), and anethole (-5.2 kcal/mol).  The four phytochemicals also appear to have good drug-likeness properties and oral bioavailability. Therefore the in vitro and in vivo studies have demonstrated that CS has strong potential as anti-arthritics and anti-inflammatory. However, clinical trials for both fresh and extracted CS are also necessary to validate the findings.