无皮疹的健康儿童感染播散性单纯疱疹病毒-1

Q3 Medicine Sultan Qaboos University Medical Journal Pub Date : 2024-06-13 DOI:10.18295/squmj.6.2024.042

Idris A. Adedeji, Abdulrahim Abdullahi, Abdulmohsen S Alharbi, Fatimah Abusrair, Mohamed Alshehri

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引用次数: 0

摘要

众所周知，播散性单纯疱疹病毒（HSV）是新生儿和免疫力低下患者的致命疾病。然而，在免疫功能正常的宿主中却鲜有病例报道。我们报告了一名一岁儿童的病例，该儿童之前身体健康，但出现发热症状并伴有意识减退。患儿肝酶明显升高。最终诊断为播散性根据脑脊液（CSF）聚合酶链反应（PCR）发现的 HSV 以及阳性 HSV 免疫球蛋白 M（IgM）血清学检查，最终诊断为播散性 HSV（脑炎/肝炎）。她接受了阿昔洛韦治疗，1 年的随访显示其发育状况良好。关键词HSV 脑炎肝炎

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Disseminated Herpes Simplex Virus-1 in Previously Healthy Child Without Skin Rash

Disseminated Herpes Simplex Virus (HSV) is a known fatal condition in neonate and immunocompromised patients. However, very few cases have been reported in immunocompetent host. We report a one year old child who was previously healthy, presented with febrile illness associated with decrease conscious level. Child has been found to have marked elevated liver enzymes. Ultimately diagnosed with disseminated. HSV (encephalitis/ hepatitis) based on Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) finding of HSV as well as positive HSV Immunoglobulin M (IgM) serology. She received acyclovir course and follow up for 1 year showed excellent developmental outcome. Keywords: HSV, Encephalitis, Hepatitis.

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