Pub Date : 2024-08-01Epub Date: 2024-08-29DOI: 10.18295/squmj.8.2024.049
{"title":"18<sup>th</sup> Asian Federation of Sports Medicine Congress cum 8<sup>th</sup> ISN international Sports Medicine & Sports Science Conference: Sabah International Convention Centre, Kota Kinabalu, Sabah, Malaysia, 26-28 April 2024.","authors":"","doi":"10.18295/squmj.8.2024.049","DOIUrl":"https://doi.org/10.18295/squmj.8.2024.049","url":null,"abstract":"","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-08-29DOI: 10.18295/squmj.6.2024.036
Dmitry V Kravchenko, Dmitry A Zinovkin, Denis A Davydov, Pavel G Kisialeu, Pavel A Kopschaj, Oleg Savchenko, Mariya Savchenko, Maryna V Barauniova, Anna S Portyanko, Md Zahidul Islam Pranjol
{"title":"Blastic Plasmacytoid Dendritic Cell Neoplasm.","authors":"Dmitry V Kravchenko, Dmitry A Zinovkin, Denis A Davydov, Pavel G Kisialeu, Pavel A Kopschaj, Oleg Savchenko, Mariya Savchenko, Maryna V Barauniova, Anna S Portyanko, Md Zahidul Islam Pranjol","doi":"10.18295/squmj.6.2024.036","DOIUrl":"10.18295/squmj.6.2024.036","url":null,"abstract":"","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-08-29DOI: 10.18295/squmj.8.2024.050
Hunain Raza, Muhammad E Bhutta, Muhammad H Siddique
{"title":"Re: Efficacy and Safety of Vildagliptin and Remogliflozin as Add-on Therapy to Metformin in Patients of Type 2 Diabetes Mellitus.","authors":"Hunain Raza, Muhammad E Bhutta, Muhammad H Siddique","doi":"10.18295/squmj.8.2024.050","DOIUrl":"10.18295/squmj.8.2024.050","url":null,"abstract":"","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18295/squmj.7.2024.047
Divya Muthuvel, Anita Soundarapandian
Mirizzi syndrome (MS), a rare complication of gallstones, refers to extrahepatic biliary compression by calculus in the cystic duct or Hartman’s pouch and is usually associated with cystic duct abnormalities. Its association with pancreatic divisum(PD) is infrequent, the most common complication of PD being recurrent pancreatitis. We report a case of 39-year-old female who presented with acute abdominal pain to the department of general surgery, Chennai, Tamil Nadu, India in August 2022. Magnetic resonance cholangiopancreaticography (MRCP) showed calculous cholecystitis with a calculus indenting the cystic duct, causing luminal narrowing of the common hepatic duct (type I), which was associated with type II PD. The association of MS with PD has been rarely described. PD may be one of the factors responsible for bile stasis leading to calculous cholecystitis and its complications. Knowledge of MS and its associations helps in early diagnosis and selection of appropriate treatment management.
米利兹综合征（Mirizzi Syndrome，MS）是胆结石的一种罕见并发症，是指胆囊管或哈特曼氏囊内的结石压迫肝外胆道，通常与胆囊管异常有关。它与胰腺憩室（PD）的关联并不常见，胰腺憩室最常见的并发症是复发性胰腺炎。我们报告了一例于 2022 年 8 月因急性腹痛就诊于印度泰米尔纳德邦钦奈市普外科的 39 岁女性病例。磁共振胆胰管造影（MRCP）显示结石性胆囊炎，结石压迫胆囊管，导致肝总管管腔狭窄（I型），与II型胰腺炎有关。多发性硬化症与腹水症相关的病例很少见。PD可能是胆汁淤积导致结石性胆囊炎及其并发症的原因之一。了解 MS 及其相关性有助于早期诊断和选择适当的治疗方法。
{"title":"A Case of Mirizzi Syndrome with Pancreatic Divisum","authors":"Divya Muthuvel, Anita Soundarapandian","doi":"10.18295/squmj.7.2024.047","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.047","url":null,"abstract":"Mirizzi syndrome (MS), a rare complication of gallstones, refers to extrahepatic biliary compression by calculus in the cystic duct or Hartman’s pouch and is usually associated with cystic duct abnormalities. Its association with pancreatic divisum(PD) is infrequent, the most common complication of PD being recurrent pancreatitis. We report a case of 39-year-old female who presented with acute abdominal pain to the department of general surgery, Chennai, Tamil Nadu, India in August 2022. Magnetic resonance cholangiopancreaticography (MRCP) showed calculous cholecystitis with a calculus indenting the cystic duct, causing luminal narrowing of the common hepatic duct (type I), which was associated with type II PD. The association of MS with PD has been rarely described. PD may be one of the factors responsible for bile stasis leading to calculous cholecystitis and its complications. Knowledge of MS and its associations helps in early diagnosis and selection of appropriate treatment management.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18295/squmj.7.2024.045
Nabaz H Ismael, N. Shabila
Objectives: This study aimed to examine the short-term effects of Mini gastric bypass (MGB) or one anastomosis gastric bypass (OAGB) procedures on weight loss in individuals with obesity. Methods: This retrospective study was conducted in Iraq from January 2019 to May 2020. 104 patients with obesity underwent MGB or OAGB surgery in a single center in Iraq. Preoperative body mass index (BMI), age, height, and preoperative weight were recorded as baseline measures. Weight-related changes were evaluated during a follow-up phase of 48 weeks. Results: The mean baseline parameters of the subjects before surgery included 1.64 meters for height, 122.9 kg for weight, and 45.6 kg/m² for BMI. During the 48-week follow-up period, there was a substantial reduction in mean weight, which dropped from 122.9 kg at baseline to 75.5 kg at week 48. The weight change (in percentage) gradually increased from -11.8% at week 12 to -37.9% at week 48, without statistically significant association with demographic factors or chronic diseases. From week 12 to week 48, the percentage of excess weight loss (%EWL) increased substantially from 26.8% to 86.1%. The results of the subgroup analysis indicated that the %EWL was considerably higher among those aged 30 or older at week 36 and singles at week 48. Conclusion: The results of this study illustrate the efficacy of MGB or OAGB procedures in significantly reducing weight in the short term. The %EWL increased with the follow up time and it was significantly associated with age and marital status.
{"title":"Short-term Weight Loss Outcomes of 104 Mini Gastric Bypass or One Anastomosis Gastric Bypass Operations","authors":"Nabaz H Ismael, N. Shabila","doi":"10.18295/squmj.7.2024.045","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.045","url":null,"abstract":"Objectives: This study aimed to examine the short-term effects of Mini gastric bypass (MGB) or one anastomosis gastric bypass (OAGB) procedures on weight loss in individuals with obesity. Methods: This retrospective study was conducted in Iraq from January 2019 to May 2020. 104 patients with obesity underwent MGB or OAGB surgery in a single center in Iraq. Preoperative body mass index (BMI), age, height, and preoperative weight were recorded as baseline measures. Weight-related changes were evaluated during a follow-up phase of 48 weeks. Results: The mean baseline parameters of the subjects before surgery included 1.64 meters for height, 122.9 kg for weight, and 45.6 kg/m² for BMI. During the 48-week follow-up period, there was a substantial reduction in mean weight, which dropped from 122.9 kg at baseline to 75.5 kg at week 48. The weight change (in percentage) gradually increased from -11.8% at week 12 to -37.9% at week 48, without statistically significant association with demographic factors or chronic diseases. From week 12 to week 48, the percentage of excess weight loss (%EWL) increased substantially from 26.8% to 86.1%. The results of the subgroup analysis indicated that the %EWL was considerably higher among those aged 30 or older at week 36 and singles at week 48. Conclusion: The results of this study illustrate the efficacy of MGB or OAGB procedures in significantly reducing weight in the short term. The %EWL increased with the follow up time and it was significantly associated with age and marital status.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18295/squmj.7.2024.046
Ahmed Al-Qassabi, Haifa Al-Abri, Mahmood Al Kindi, Abdullah Al-Asmi, Jalila Alshekaili, Said Al Farsi, Rawan Al Hinai, Ikram Al Lawati, A. Gujjar
The incidence of autoimmune encephalitis (AE) is rising due to increased awareness of the condition and detection of new autoantibodies. Coinciding with this rise are false positive autoantibodies without clinical correlates. Objective: To explore the clinical profiles of Omani patients who are truly positive for AE autoantibodies and compare them with those with false-positive autoantibodies. Methods: We reviewed the medical records of all patients who tested positive for AE antibody from May 2016 to December 2022. Cases were verified by three neurologists based on the existing criteria for AE. Results: The participants comprised N = 67 patients, 19 (28%) of whom fulfilled the criteria for AE. True-positive AE patients were younger with mean age of 35.3 ± 4.7 years (p = 0.010). They were also more likely to present with subacute memory disturbances (6/19; 32%; p = 0.030), seizures (12; 63%; p = 0.028), abnormal electroencephalogram (EEG) findings (10; 65%; p = 0.040), and abnormal signals in limbic region on magnetic resonance imaging (MRI) (5; 26%; p = 0.010). Subacute memory disturbance was a significant predictor for true positivity (OR = 17.807, 95%CI = 1.608–197.202; p = 0.019). Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis was the most frequent type of AE (8; 42.1%), followed by anti-glutamic acid decarboxylase 65 (GAD65) (4; 21.1%). Conclusion: Of the 67 cases with positive AE autoantibody panel, 48 (72%) were false-positive. The presence of subacute memory impairment was a significant predictor of AE. Anti-NMDAR encephalitis was the most frequent AE encountered in our cohort.
{"title":"Clinical and Autoimmune Profiles of Omani Patients with True Versus False Positive Autoimmune Encephalitis Antibodies Panels","authors":"Ahmed Al-Qassabi, Haifa Al-Abri, Mahmood Al Kindi, Abdullah Al-Asmi, Jalila Alshekaili, Said Al Farsi, Rawan Al Hinai, Ikram Al Lawati, A. Gujjar","doi":"10.18295/squmj.7.2024.046","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.046","url":null,"abstract":"The incidence of autoimmune encephalitis (AE) is rising due to increased awareness of the condition and detection of new autoantibodies. Coinciding with this rise are false positive autoantibodies without clinical correlates. Objective: To explore the clinical profiles of Omani patients who are truly positive for AE autoantibodies and compare them with those with false-positive autoantibodies. Methods: We reviewed the medical records of all patients who tested positive for AE antibody from May 2016 to December 2022. Cases were verified by three neurologists based on the existing criteria for AE. Results: The participants comprised N = 67 patients, 19 (28%) of whom fulfilled the criteria for AE. True-positive AE patients were younger with mean age of 35.3 ± 4.7 years (p = 0.010). They were also more likely to present with subacute memory disturbances (6/19; 32%; p = 0.030), seizures (12; 63%; p = 0.028), abnormal electroencephalogram (EEG) findings (10; 65%; p = 0.040), and abnormal signals in limbic region on magnetic resonance imaging (MRI) (5; 26%; p = 0.010). Subacute memory disturbance was a significant predictor for true positivity (OR = 17.807, 95%CI = 1.608–197.202; p = 0.019). Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis was the most frequent type of AE (8; 42.1%), followed by anti-glutamic acid decarboxylase 65 (GAD65) (4; 21.1%). Conclusion: Of the 67 cases with positive AE autoantibody panel, 48 (72%) were false-positive. The presence of subacute memory impairment was a significant predictor of AE. Anti-NMDAR encephalitis was the most frequent AE encountered in our cohort.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18295/squmj.7.2024.044
Nadiya Al Saeghi, Marwah Al Thuhli, Hajer Al Hamrashi, Naema Al Shibli, Adil Al Wahaibi, Badriya Al Adawi, Laila S. Al Yazidi
Objectives: Little is known about bloodstream infection (BSI) among children in Oman. This study was done to assess the local epidemiology and outcome of BSI among Omani children. Methods: A retrospective study of laboratory-confirmed BSI was conducted among children (0 -12 years) managed at Sultan Qaboos University Hospital, Oman, over a 5-year period (2014-2018). Patients’ demographic, clinical, and laboratory data were extracted from the hospital’s electronic records and were used to assess BSI rates and outcome. Results: A total of 1253 positive blood cultures were identified of which 592 (47.2%) were regarded as contaminants. Overall, 404 (32.2%) significant episodes of BSI were identified in 272 patients of whom 346 (85.6%) were ≤ 5 years of age and 366 (90.6%) had comorbidities. The 5-years incidence of BSI was 13 per 1000 admissions. Three hundred and thirty-three (82.4%) episodes were healthcare-related infections. Enterobacterales (152; 37.6%) were the most common organisms identified followed by coagulase-negative staphylococci (63; 15.5%). About 40% of Gram-negative organisms were resistant to 3rd generation cephalosporins. The crude mortality rate at 30 days was 9.2%. Pediatric Intensive Care Units admission (COR = 2.24, 95% CI: 0.98-4.78) and the presence of Graft-Versus-Host Disease (COR = 7.99, 95% CI: 1.52-37.76) were associated with increased death within 30 days. The multivariate logistic regression analysis showed that Pseudomonas aeruginosa (AOR = 18.46, 95% CI: 3.96-97.84) was the only independent predictor of increasing 30-day mortality in this cohort. Conclusions: This study found a high rate of hospital-related BSI in children in Oman. This highlights the need to optimize infection control strategies and the care of central vein access devices.
{"title":"Bloodstream Infection in Children Managed at a Tertiary Hospital in Oman","authors":"Nadiya Al Saeghi, Marwah Al Thuhli, Hajer Al Hamrashi, Naema Al Shibli, Adil Al Wahaibi, Badriya Al Adawi, Laila S. Al Yazidi","doi":"10.18295/squmj.7.2024.044","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.044","url":null,"abstract":"Objectives: Little is known about bloodstream infection (BSI) among children in Oman. This study was done to assess the local epidemiology and outcome of BSI among Omani children. Methods: A retrospective study of laboratory-confirmed BSI was conducted among children (0 -12 years) managed at Sultan Qaboos University Hospital, Oman, over a 5-year period (2014-2018). Patients’ demographic, clinical, and laboratory data were extracted from the hospital’s electronic records and were used to assess BSI rates and outcome. Results: A total of 1253 positive blood cultures were identified of which 592 (47.2%) were regarded as contaminants. Overall, 404 (32.2%) significant episodes of BSI were identified in 272 patients of whom 346 (85.6%) were ≤ 5 years of age and 366 (90.6%) had comorbidities. The 5-years incidence of BSI was 13 per 1000 admissions. Three hundred and thirty-three (82.4%) episodes were healthcare-related infections. Enterobacterales (152; 37.6%) were the most common organisms identified followed by coagulase-negative staphylococci (63; 15.5%). About 40% of Gram-negative organisms were resistant to 3rd generation cephalosporins. The crude mortality rate at 30 days was 9.2%. Pediatric Intensive Care Units admission (COR = 2.24, 95% CI: 0.98-4.78) and the presence of Graft-Versus-Host Disease (COR = 7.99, 95% CI: 1.52-37.76) were associated with increased death within 30 days. The multivariate logistic regression analysis showed that Pseudomonas aeruginosa (AOR = 18.46, 95% CI: 3.96-97.84) was the only independent predictor of increasing 30-day mortality in this cohort. Conclusions: This study found a high rate of hospital-related BSI in children in Oman. This highlights the need to optimize infection control strategies and the care of central vein access devices.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18295/squmj.7.2024.043
Evan H. Sulaiman, L. J. Mohammad, Allaa H. Thanoon, Isaac Karimi
Objectives: The role of serum cholesterol and its interactions with cytokines in the pathophysiology of human cutaneous leishmaniasis (CL) is not known. This study was aimed to evaluate the correlation between serum total cholesterol (TC), very-low-density lipoprotein-cholesterol (VLDL-C), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and triglycerides (TG), and cytokines including interleukin-10 (IL10), interleukin-12 (IL12), tumor necrosis factor-alpha (TNF-α), in CL. Moreover, we analyzed the cholesterol-cytokine network to shed light on the pathogenesis of CL. Methods: A case-control study including CL patients (n = 50) and control subjects (n = 25) ranging between 20-30 years old was conducted from December 2022 to March 2023. The serum samples were analyzed via commercial kits to detect the levels of TC, IL-10, IL-12, TNF-α, VLDL-C, LDL-C, HDL-C and TG. Computational efforts to dissect cholesterol-protein interaction networks was also employed using STITCH. Results: TC, HDL-C, and LDL-C levels were markedly lower (p =0.0001) in CL patients compared to those of control subjects, whereas IL10, IL12, TNF-α, VLDL-C and TG levels were higher in CL patients. Serum cholesterol did not exhibit a correlation with cytokines, however a significant correlation (r = 0.57; p = 0.026) was observed between IL12 and TNF-α. Within the cholesterol-protein network, cholesterol potentially interacted with IL10, connecting cholesterol to modules with immunological significance, including TARAF1, TARAF2, and TNFRSF1B, as well as IL10, IL10RA, and IL12RB1. Conclusion: This study showed alteration of lipid and lipoprotein in CL, and it introduced two immunological modules in CL which appreciates attention to the altered cholesterol-cytokine interaction network in CL.
{"title":"Immuno-Informatics Insight into Relationship Between Cholesterol and Cytokines in Cutaneous Leishmaniasis","authors":"Evan H. Sulaiman, L. J. Mohammad, Allaa H. Thanoon, Isaac Karimi","doi":"10.18295/squmj.7.2024.043","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.043","url":null,"abstract":"Objectives: The role of serum cholesterol and its interactions with cytokines in the pathophysiology of human cutaneous leishmaniasis (CL) is not known. This study was aimed to evaluate the correlation between serum total cholesterol (TC), very-low-density lipoprotein-cholesterol (VLDL-C), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and triglycerides (TG), and cytokines including interleukin-10 (IL10), interleukin-12 (IL12), tumor necrosis factor-alpha (TNF-α), in CL. Moreover, we analyzed the cholesterol-cytokine network to shed light on the pathogenesis of CL. Methods: A case-control study including CL patients (n = 50) and control subjects (n = 25) ranging between 20-30 years old was conducted from December 2022 to March 2023. The serum samples were analyzed via commercial kits to detect the levels of TC, IL-10, IL-12, TNF-α, VLDL-C, LDL-C, HDL-C and TG. Computational efforts to dissect cholesterol-protein interaction networks was also employed using STITCH. Results: TC, HDL-C, and LDL-C levels were markedly lower (p =0.0001) in CL patients compared to those of control subjects, whereas IL10, IL12, TNF-α, VLDL-C and TG levels were higher in CL patients. Serum cholesterol did not exhibit a correlation with cytokines, however a significant correlation (r = 0.57; p = 0.026) was observed between IL12 and TNF-α. Within the cholesterol-protein network, cholesterol potentially interacted with IL10, connecting cholesterol to modules with immunological significance, including TARAF1, TARAF2, and TNFRSF1B, as well as IL10, IL10RA, and IL12RB1. Conclusion: This study showed alteration of lipid and lipoprotein in CL, and it introduced two immunological modules in CL which appreciates attention to the altered cholesterol-cytokine interaction network in CL.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18295/squmj.7.2024.048
Yasser K Al Lawati, Darapanarayan Hazra, Awatif KA Al-Alawi, Suad Al Abri
Acute carbon monoxide (CO) poisoning significantly impacts neurological function, stemming from incomplete combustion of carbon-containing materials, posing a substantial risk. Symptoms range from mild headaches to severe neurological complications, complicating diagnosis. Primary treatment involves supplemental oxygen via a nonrebreather mask. Hyperbaric oxygen therapy (HBOT), though debated, initiated within six hours, may enhance carboxyhemoglobin (CO-Hb) elimination and tissue oxygenation, even with decreased CO-Hb levels. Our report outlines the case of an elderly woman who arrived at the emergency department with symptoms initially suggestive of a cerebrovascular event. However, further history and examination revealed indications of acute CO poisoning, likely due to exposure to a charcoal-burning heater. Despite stable vital signs, her CO-Hb and lactates levels were high. Treatment with normobaric oxygen therapy resulted in some improvement, but significant neurological recovery was achieved with HBOT. This case represents the first documented instance of successful HBOT treatment for acute CO toxicity in Oman.
{"title":"A Rare Case of Acute Carbon Monoxide Toxicity Mimicking Stroke and Successfully Managed with Hyperbaric Oxygen Therapy","authors":"Yasser K Al Lawati, Darapanarayan Hazra, Awatif KA Al-Alawi, Suad Al Abri","doi":"10.18295/squmj.7.2024.048","DOIUrl":"https://doi.org/10.18295/squmj.7.2024.048","url":null,"abstract":"Acute carbon monoxide (CO) poisoning significantly impacts neurological function, stemming from incomplete combustion of carbon-containing materials, posing a substantial risk. Symptoms range from mild headaches to severe neurological complications, complicating diagnosis. Primary treatment involves supplemental oxygen via a nonrebreather mask. Hyperbaric oxygen therapy (HBOT), though debated, initiated within six hours, may enhance carboxyhemoglobin (CO-Hb) elimination and tissue oxygenation, even with decreased CO-Hb levels. Our report outlines the case of an elderly woman who arrived at the emergency department with symptoms initially suggestive of a cerebrovascular event. However, further history and examination revealed indications of acute CO poisoning, likely due to exposure to a charcoal-burning heater. Despite stable vital signs, her CO-Hb and lactates levels were high. Treatment with normobaric oxygen therapy resulted in some improvement, but significant neurological recovery was achieved with HBOT. This case represents the first documented instance of successful HBOT treatment for acute CO toxicity in Oman.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.038
Abdulla Alfutaisi, Alaa Osman, Zainab S Al Siyabi, Osama S Al Senani, Fatima Bahowairath, Ahmed Al Farqani, Sara K Al Rasbi
Thyroid eye disease (TED) is the most common symptoms of Graves’ disease. This condition commonly manifests bilaterally and symmetrically. The most prominent symptoms are lid retraction, exophthalmos, and diplopia. Rarely, individuals with Graves’ disease may show asymmetrical or unilateral eye symptoms. Marine-Lenhart syndrome is a variant of Graves’ disease with occasional hyperactive nodules. We introduce a 36-year-old Omani male patient who presented to the endocrinology outpatient department of Sultan Qaboos University Hospital, Muscat, Oman, in 2022 with unilateral eye proptosis and was subsequently found to have Graves’ disease. This case presents a rare Graves’ disease variant with unilateral goiter and orbitopathy. Keywords: Graves’ disease; Unilateral proptosis; Thyroid Eye Disease; Graves ’orbitopathy; Marine-Lenhart syndrome.
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