N,N-二甲基甲酰胺二甲基缩醛 (DMFDMA)：从衍生到 C1 合物

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-13 DOI:10.1071/ch24020

Natalie Ferreira Araujo, Sabrina Baptista Ferreira

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引用次数: 0

摘要

N,N-二甲基甲酰胺二甲基缩醛（DMFDMA）又称 1,1-二甲氧基-N,N-二甲基甲胺，是一种无色有酸臭味的液体。DMFDMA 的化学结构有两个重要部位，一个是在缩合反应中作为亲电子体的部分正碳，另一个是作为亲核体的部分负氮。由于其结构，DMFDMA 可与许多不同的有机基团发生反应，是一种用途广泛的试剂，可用于气相色谱法、作为保护基团和 C1 合剂，尤其是用于构建杂环。

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N,N-Dimethylformamide dimethyl acetal (DMFDMA): from derivatisation to C1 synthon

N,N-Dimethylformamide dimethyl acetal (DMFDMA), also called 1,1-dimethoxy-N,N-dimethylmethanamine, is a colorless liquid with rancid odour. The chemical structure of DMFDMA presents two important sites, a partially positive carbon that acts as an electrophile in condensation reactions and a partially negative nitrogen that acts as a nucleophile. Because of its structure, DMFDMA reacts with many different organic groups and can be a versatile reagent used in gas chromatography, as a protecting group and as a C1 synthon, especially in the construction of heterocycles.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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