{"title":"鸟类迁徙行为的调节基础:通往相似结果的不同道路","authors":"Violeta Caballero-López, Staffan Bensch","doi":"10.1111/jav.03238","DOIUrl":null,"url":null,"abstract":"Animal migration is a fascinating phenomenon that has puzzled mankind since the time of ancient Greece. It is a process widespread across a varied range of taxa and it shines especially in birds which, because of their mobility, display an amazing diversity of routes and strategies. With the advances in tracking devices and improvements of sequencing technologies, recent work provides support for a strong genetic influence of several migratory traits across different species. However, there is little to no evidence of any common sequence‐based mechanism behind this complex behaviour, nor any unifying principle explaining it. We review how the focus in understanding the genetic basis for migratory traits should be shifted towards studying regulatory mechanisms of gene expression instead of the traditional candidate gene approach. Importantly, a role for gene expression as the underlying driver of the migratory phenotype can resolve the opposing and often strong views that migration is mainly either under genetic or environmental influence. We emphasise that research should take new directions, reinforcing that there is probably not a common genetic basis for how migration is regulated in birds. Here, we support the notion that 1) migration can only evolve this fast if it is a quantitative trait with a large standing variation; 2) the main drivers for migration evolution seem to be diverse expression–regulation mechanisms rather than gene‐level polymorphisms; and 3) non‐coding sequences of the genome, epigenetics and structural variation might be more important in shaping complex traits than previously thought. Further, we present several hypotheses outlining how these regulatory mechanisms might work across different bird species defining certain migratory traits.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The regulatory basis of migratory behaviour in birds: different paths to similar outcomes\",\"authors\":\"Violeta Caballero-López, Staffan Bensch\",\"doi\":\"10.1111/jav.03238\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Animal migration is a fascinating phenomenon that has puzzled mankind since the time of ancient Greece. It is a process widespread across a varied range of taxa and it shines especially in birds which, because of their mobility, display an amazing diversity of routes and strategies. With the advances in tracking devices and improvements of sequencing technologies, recent work provides support for a strong genetic influence of several migratory traits across different species. However, there is little to no evidence of any common sequence‐based mechanism behind this complex behaviour, nor any unifying principle explaining it. We review how the focus in understanding the genetic basis for migratory traits should be shifted towards studying regulatory mechanisms of gene expression instead of the traditional candidate gene approach. Importantly, a role for gene expression as the underlying driver of the migratory phenotype can resolve the opposing and often strong views that migration is mainly either under genetic or environmental influence. We emphasise that research should take new directions, reinforcing that there is probably not a common genetic basis for how migration is regulated in birds. Here, we support the notion that 1) migration can only evolve this fast if it is a quantitative trait with a large standing variation; 2) the main drivers for migration evolution seem to be diverse expression–regulation mechanisms rather than gene‐level polymorphisms; and 3) non‐coding sequences of the genome, epigenetics and structural variation might be more important in shaping complex traits than previously thought. Further, we present several hypotheses outlining how these regulatory mechanisms might work across different bird species defining certain migratory traits.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1111/jav.03238\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1111/jav.03238","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
The regulatory basis of migratory behaviour in birds: different paths to similar outcomes
Animal migration is a fascinating phenomenon that has puzzled mankind since the time of ancient Greece. It is a process widespread across a varied range of taxa and it shines especially in birds which, because of their mobility, display an amazing diversity of routes and strategies. With the advances in tracking devices and improvements of sequencing technologies, recent work provides support for a strong genetic influence of several migratory traits across different species. However, there is little to no evidence of any common sequence‐based mechanism behind this complex behaviour, nor any unifying principle explaining it. We review how the focus in understanding the genetic basis for migratory traits should be shifted towards studying regulatory mechanisms of gene expression instead of the traditional candidate gene approach. Importantly, a role for gene expression as the underlying driver of the migratory phenotype can resolve the opposing and often strong views that migration is mainly either under genetic or environmental influence. We emphasise that research should take new directions, reinforcing that there is probably not a common genetic basis for how migration is regulated in birds. Here, we support the notion that 1) migration can only evolve this fast if it is a quantitative trait with a large standing variation; 2) the main drivers for migration evolution seem to be diverse expression–regulation mechanisms rather than gene‐level polymorphisms; and 3) non‐coding sequences of the genome, epigenetics and structural variation might be more important in shaping complex traits than previously thought. Further, we present several hypotheses outlining how these regulatory mechanisms might work across different bird species defining certain migratory traits.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.