摘要 IA017：肿瘤进化过程中产生的合成依赖性

IF 5.3 2区医学 Q1 ONCOLOGY Molecular Cancer Therapeutics Pub Date : 2024-06-10 DOI:10.1158/1538-8514.synthleth24-ia017

Kris C. Wood

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引用次数: 0

摘要

我们的研究重点是定义肿瘤选择性生存依赖性，并了解这些依赖性在肿瘤进化过程中如何变化。在本讲座中，我将概述我们实验室的工作，重点介绍最近和正在进行的研究，这些研究揭示了残留肿瘤和完全耐药肿瘤中出现的基于机制的合成致死性，利用这些机制进行治疗有可能选择性地对抗最具侵袭性的疾病。引用格式：克里斯-C-伍德肿瘤进化过程中产生的合成依赖性[摘要].In：AACR 癌症研究特别会议论文集：扩展和转化癌症合成脆弱性；2024 年 6 月 10-13 日；加拿大魁北克省蒙特利尔。费城（宾夕法尼亚州）：AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr IA017.

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Abstract IA017: Synthetic dependencies arising during tumor evolution

Our research focuses on defining tumor-selective survival dependencies and understanding how these dependencies change during tumor evolution. In this talk, I will provide an overview of our lab’s work, highlighting recent and ongoing studies uncovering mechanism-based synthetic lethalities arising in residual and fully drug resistant tumors whose therapeutic exploitation has the potential to select against the most aggressive forms of disease. Citation Format: Kris C. Wood. Synthetic dependencies arising during tumor evolution [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr IA017.

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来源期刊

Molecular Cancer Therapeutics 医学-肿瘤学

CiteScore

11.20

自引率

1.80%

发文量

331

审稿时长

3 months

期刊介绍： Molecular Cancer Therapeutics will focus on basic research that has implications for cancer therapeutics in the following areas: Experimental Cancer Therapeutics, Identification of Molecular Targets, Targets for Chemoprevention, New Models, Cancer Chemistry and Drug Discovery, Molecular and Cellular Pharmacology, Molecular Classification of Tumors, and Bioinformatics and Computational Molecular Biology. The journal provides a publication forum for these emerging disciplines that is focused specifically on cancer research. Papers are stringently reviewed and only those that report results of novel, timely, and significant research and meet high standards of scientific merit will be accepted for publication.