GSK3: The Shared Target of Circadian Rhythm and Lithium Treatment in Bipolar Disorder

Bipolar disorder is a severe emotional disorder that causes significant damage to patients’ cognitive functions. Although the clinical manifestations of bipolar disorder are clear, its pathophysiological mechanisms are currently not well understood. The theme of this review is to explore the pathophysiological mechanisms of bipolar disorder. Starting from the lithium treatment mechanism, the author identified an important target - GSK-3, by reviewing previous literature. Research has shown that GSK-3 plays a crucial role in the bipolar disorder. This review provides an introduction to GSK-3 and its probable mechanisms that contribute to bipolar disease. It also examines the role of GSK-3 in bipolar disorder from both the standpoint of how it develops and how it might be treated. By studying GSK-3, we can augment our comprehension of bipolar disorder and further delve into our grasp of this condition.