考虑到拦截器-保护器作用理论的四组件系统简化模型分析

I. Golovchenko, V. Ratnikov
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摘要

本文提供了一种使用与拦截器-保护器作用理论一致的模型分析四组件系统的方法。所给出的模型是对已经研究得很透彻的三组份系统的进一步发展,之前已经在没有符号和图形解决方案的情况下进行了演示。该理论的各要素提出了一种完整的分析算法,有可能应用于任何 DNA 特异性芳香药物混合物系统;抑制干扰生物相关分子相互作用的有害制剂的有害效应的成分,或反过来说,抑制催化制剂的成分。此类分析模型对于设计新药物以调节其药效和靶向性非常重要。在本文中,系统中的第四组分被认为是三组分系统中的特异性拦截剂/保护剂,对第三组分的抑制活性起调节作用,而与其他两组分的任何相互作用则被完全忽略。只有在与第四种成分的亲和力完全不存在或无限大的极端情况下,才会给出模型的完整图示。通过跟踪实验点与前面提到的图形之一的接近程度,可以对真实的四成分系统图形进行定性分析。
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ANALYSIS OF THE FOUR-COMPONENT SYSTEM REDUCED MODEL CONSIDERING THE THEORY OF INTERCEPTOR-PROTECTOR ACTION
This paper provides a means of analysing a four-component system using a model consistent with the theory of interceptor-protector action. The given model is a further development of already well-studied three-component systems and was previously demonstrated without a symbolic and graphical solution. Elements of the theory present a complete analytical algorithm that can potentially be applied to any system of DNA-specific mixtures of aromatic drugs; components that inhibit the deleterious effects of noxious agents that interfere with biologically relevant molecular interactions, or conversely, inhibitors of catalytic agents. Such analytical models are important in the context of designing new drugs to regulate their efficacy and targeting. For the purposes of this article, the fourth component of the system is considered to be specific to the interceptor/protector in a three-component system, acting as a regulator of the inhibitory activity of the third component, with any interaction with the other two components being completely ignored. A full graphical representation of the model is given only for the extreme cases where the affinity to the fourth component is either completely absent or infinite. The qualitative analysis of the graph of the real four-component system is carried out by tracking the proximity of the experimental points to one of the previously mentioned graphs.
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