石墨烯氧化物纳米载体在乳腺癌治疗中的有效药物传输

Mahshid Sadeghi
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引用次数: 0

摘要

乳腺癌是全球最常见的癌症,女性患病风险较高。目前的治疗方法,如手术、化疗和放疗,由于肿瘤的异质性和错综复杂的调节,都遇到了很大的困难。纳米技术,尤其是氧化石墨烯(GO)的利用,为克服传统治疗方法的局限性提供了一种前景广阔的方法。氧化石墨烯的独特性质,包括二维结构、功能基团和高表面积,使其成为开发多功能纳米载体的理想材料。基于氧化石墨烯的纳米载体克服了化疗的局限性和不良反应,在乳腺癌治疗中展现出巨大的潜力。使用壳聚糖和聚乙二醇等生物相容性物质对 GO 表面进行功能化,可提高 GO 的细胞毒性。增强细胞毒性还能提高治疗对传统疗法产生抗药性的肿瘤的能力。这些研究结果表明,基于GO的纳米载体在治疗乳腺癌方面具有良好的疗效,并为今后开发更精确、更高效的治疗策略铺平了道路,从而有可能改善治疗效果。
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Graphene Oxide Nanocarriers for Effective Drug Delivery in Breast Cancer Treatment
Breast cancer is the most commonly diagnosed form of cancer globally, with women having a higher risk of developing the disease. Current treatment approaches, such as surgery, chemotherapy, and radiotherapy, encounter significant difficulties due to the heterogeneous and intricate regulation of tumors. Nanotechnology, especially the utilization of graphene oxide (GO), presents a promising approach to overcoming the limitations of traditional treatments. GO's unique properties, including its two-dimensional structure, functional groups, and high surface area, make it an ideal material for developing multifunctional nanocarriers. Graphene oxide-based nanocarriers have demonstrated immense potential in breast cancer therapeutics by overcoming the limitations and adverse reactions associated with chemotherapy. The functionalization of GO's surface using biocompatible substances like chitosan and polyethylene glycol improves the cytotoxicity of GO. Enhancing the cytotoxicity also improves the ability to treat tumors that have developed resistance to traditional treatments. These findings demonstrate the promising efficacy of GO-based nanocarriers in treating breast cancer and pave the way for the development of more precise and efficient treatment strategies in the future, potentially improving therapeutic outcomes.
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