基于氮杂-BODIPY 的近红外-II 辐射纳米粒子用于触发脑胶质母细胞瘤凋亡

IF 8.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chinese Chemical Letters Pub Date : 2025-05-01 Epub Date: 2024-06-06 DOI:10.1016/j.cclet.2024.110098

Mengjie Gao , Zhiqiang Cui , Yue Shen , Yikun Li , Dongxiang Zhang , Xiaoyan Gao , Yaguang Sun , Xin-Dong Jiang , Jianjun Du , Xiaohong Sun

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引用次数: 0

摘要

采用Suzuki交叉偶联反应制备了D-D′-A型氮杂硼二吡咯烯（aza-BODIPYs）。在近红外（NIR）照射下，具有NIR- ii发射（λem = 1065 nm）的自组装aza- bodipy纳米粒子（DA-azaBDP-NPs）的光热转换效率为37.2% %，且DA-azaBDP-NPs与NIR照射共存时具有显著的细胞毒性，可减少胶质母细胞瘤的迁移，抑制胶质母细胞瘤的增殖。DA-azaBDP-NPs可促进胶质母细胞瘤自噬，加速细胞死亡过程。DA-azaBDP-NPs光热疗法（PTT）能在近红外照射下有效诱导胶质母细胞瘤凋亡死亡，在脑内实验中应用前景广阔。

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NIR-II emissive aza-BODIPY-based nanoparticles for triggering glioblastoma apoptosis in brain

D-D’-A type aza-borondipyrromethenes (aza-BODIPYs) were prepared by Suzuki cross-coupling reaction. Photothermal conversion efficiency of self-assemble aza-BODIPY-based nanoparticles (DA-azaBDP-NPs) with NIR-II emission (λ_em = 1065 nm) was 37.2 % under near infrared (NIR) irradiation, and the outstanding cytotoxicity was triggered by coexistence of DA-azaBDP-NPs and the NIR irradiation, with the decrease of glioblastoma migration and the inhibition of glioblastoma proliferation. DA-azaBDP-NPs could promote glioblastoma autophagy and accelerate the process of cell death. The photothermal therapy (PTT) of DA-azaBDP-NPs can effectively induce glioblastoma death by apoptosis under the NIR irradiation, which is highly promising to be applied in vivo experiments of brain.

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来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.