铜催化炔烯丙基酯与吡唑酮的不对称 [4 + 1] 环化反应

IF 9.5 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chinese Chemical Letters Pub Date : 2025-04-01 Epub Date: 2024-06-13 DOI:10.1016/j.cclet.2024.110114

Guang Xu , Cuiju Zhu , Xiang Li, Kexin Zhu, Hao Xu

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引用次数: 0

摘要

采用铜催化的远程策略，实现了乙烯丙基乙酸酯与吡唑酮直接[4 + 1]环化的对映选择性催化方法。各种对映体富集的螺吡唑啉类药物可以快速高产地获得，对映体控制适中。简单的后续转化突出了其在合成各种螺吡唑酮构建块中的潜在效用。

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Copper-catalyzed asymmetric [4+1] annulation of yne‑allylic esters with pyrazolones

An enantioselective catalytic method for the direct [4 + 1] annulation of yne‑allylic acetates with pyrazolones has been realized by a copper-catalyzed remote strategy. A variety of enantioenriched spiropyrazolones are rapidly accessed in high yields with moderate to good enantiocontrol. The facile follow-up transformations highlight its potential utility in the synthesis of diverse spiropyrazolones building blocks.

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来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.