从新氧化还原蛋白中构建量身定制的生物能蛋白和电路

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Electrochemistry Pub Date : 2024-06-05 DOI:10.1016/j.coelec.2024.101541
Benjamin J. Hardy , Ethan L. Bungay , Cam Mellor , Paul Curnow , J.L. Ross Anderson
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引用次数: 0

摘要

天然电子传导回路在呼吸作用和光合作用中发挥着至关重要的作用,因此对地球上的所有生命都至关重要。这些回路由蛋白质或多亚基蛋白质复合物中具有氧化还原作用的辅助因子组成,可促进电子传导,支持跨膜质子泵、氧化还原催化和细胞外向终端电子受体输送电子。虽然自然界的电子传导电路可能很复杂,但我们仍有可能在从头设计的极简蛋白质中重现选定的理想功能。在这里,我们将重点介绍从头设计氧化还原蛋白和酶的最新进展,这些进展说明了这种方法的进步和潜力,让人们深入了解其天然对应物的工作原理和工程学,同时为未来的生物电子工程创造一套易于适应且稳健的组件。
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Building tailor-made bioenergetic proteins and circuits from de novo redox proteins

Natural electron-conducting circuits play essential roles in respiration and photosynthesis and are therefore of fundamental importance to all life on earth. These circuits are composed of redox-active cofactors housed within proteins, or multi-subunit protein complexes, facilitating the conduction of electrons in support of transmembrane proton pumping, redox catalysis and the extracellular delivery of electrons to terminal electron acceptors. Though the natural electron-conducting circuitry can be complex, it is possible to recapitulate selected, desirable functions within minimalist de novo-designed proteins. Here we highlight recent advances in the de novo design of redox proteins and enzymes that illustrate the progress and potential of this approach, providing insight into the workings and engineering of their natural counterparts, while creating a readily adaptable and robust set of components for future bioelectronic engineering.

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来源期刊
Current Opinion in Electrochemistry
Current Opinion in Electrochemistry Chemistry-Analytical Chemistry
CiteScore
14.00
自引率
5.90%
发文量
272
审稿时长
73 days
期刊介绍: The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner: 1.The views of experts on current advances in electrochemistry in a clear and readable form. 2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle: • Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •
期刊最新文献
Determination of the reaction orders for electrode reactions Electrochemical systems for renewable energy conversion and storage: Focus on flow batteries and regenerative fuel cells Advancements in ordered membrane electrode assembly (MEA) for water electrolysis Artificial protective layers of zinc metal anodes for reversible aqueous zinc ion batteries The chemical effect of a selenium atom on the catalytic site of precious metals
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