Alexandra Juhász , Peter Makaula , Lucas J. Cunningham , Sam Jones , John Archer , David Lally JR , Gladys Namacha , Donales Kapira , Priscilla Chammudzi , E. James LaCourse , Edmund Seto , Sekeleghe A. Kayuni , Janelisa Musaya , J. Russell Stothard
{"title":"揭示马拉维的牛血吸虫病:连接牛体内的人类血吸虫和杂交血吸虫","authors":"Alexandra Juhász , Peter Makaula , Lucas J. Cunningham , Sam Jones , John Archer , David Lally JR , Gladys Namacha , Donales Kapira , Priscilla Chammudzi , E. James LaCourse , Edmund Seto , Sekeleghe A. Kayuni , Janelisa Musaya , J. Russell Stothard","doi":"10.1016/j.onehlt.2024.100761","DOIUrl":null,"url":null,"abstract":"<div><p>In Malawi, the putative origin of a newly described <em>Schistosoma haematobium</em>-<em>mattheei</em> hybrid human schistosome was assessed upon a seminal molecular parasitological survey of cattle. Using miracidia hatch test (MHT) and carcass inspection at slaughter, mean prevalence of bovine schistosomiasis was 49.1% (95% CI: 43.7–54.6%) and 10.3% (95% CI: 6.0–16.2%) respectively, though significant spatial heterogeneity was noted. Approximately 2.0% of infected cattle, and only those from Mangochi District, shed <em>S. haematobium</em>-<em>mattheei</em> and/or <em>S. haematobium</em> in faeces. To quantify schistosome (re)infection dynamics, where a <em>S. haematobium</em>-<em>mattheei</em> hybrid was present, we undertook a novel pilot GPS-datalogging sub-study within a specific herd of cattle (<em>n</em> = 8) on the Lake Malawi shoreline, alongside a praziquantel (40 mg/kg) treatment efficacy spot check. At sub-study baseline, all GPS-tagged cattle had proven daily water contact with the lake. Each animal was patently infected upon MHT, with older animals shedding less miracidia. At one month review, whilst parasitological cure was 100.0%, from six weeks onwards, (re)infection was first noted in the youngest animal. By three-month review, all animals were patently (re)infected though only miracidia of <em>S. mattheei</em> were recovered, albeit in much lower numbers. To conclude, infection with <em>S. mattheei</em> is particularly common in cattle and demonstrates a previously cryptic burden of bovine schistosomiasis. Within Mangochi District, bovine transmission of both <em>S. haematobium</em>-<em>mattheei</em> hybrids and <em>S. haematobium</em> are now incriminated, with unequivocal evidence of contemporary zoonotic spill-over. Future control of urogenital schistosomiasis here in the southern region needs to develop, then successfully integrate, a One Health approach with appropriate mitigating strategies to reduce and/or contain bovine schistosomiasis transmission.</p></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352771424000879/pdfft?md5=0a67ea59ce6d42fb5920a8cfa1ecef75&pid=1-s2.0-S2352771424000879-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Revealing bovine schistosomiasis in Malawi: Connecting human and hybrid schistosomes within cattle\",\"authors\":\"Alexandra Juhász , Peter Makaula , Lucas J. Cunningham , Sam Jones , John Archer , David Lally JR , Gladys Namacha , Donales Kapira , Priscilla Chammudzi , E. James LaCourse , Edmund Seto , Sekeleghe A. Kayuni , Janelisa Musaya , J. Russell Stothard\",\"doi\":\"10.1016/j.onehlt.2024.100761\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In Malawi, the putative origin of a newly described <em>Schistosoma haematobium</em>-<em>mattheei</em> hybrid human schistosome was assessed upon a seminal molecular parasitological survey of cattle. Using miracidia hatch test (MHT) and carcass inspection at slaughter, mean prevalence of bovine schistosomiasis was 49.1% (95% CI: 43.7–54.6%) and 10.3% (95% CI: 6.0–16.2%) respectively, though significant spatial heterogeneity was noted. Approximately 2.0% of infected cattle, and only those from Mangochi District, shed <em>S. haematobium</em>-<em>mattheei</em> and/or <em>S. haematobium</em> in faeces. To quantify schistosome (re)infection dynamics, where a <em>S. haematobium</em>-<em>mattheei</em> hybrid was present, we undertook a novel pilot GPS-datalogging sub-study within a specific herd of cattle (<em>n</em> = 8) on the Lake Malawi shoreline, alongside a praziquantel (40 mg/kg) treatment efficacy spot check. At sub-study baseline, all GPS-tagged cattle had proven daily water contact with the lake. Each animal was patently infected upon MHT, with older animals shedding less miracidia. At one month review, whilst parasitological cure was 100.0%, from six weeks onwards, (re)infection was first noted in the youngest animal. By three-month review, all animals were patently (re)infected though only miracidia of <em>S. mattheei</em> were recovered, albeit in much lower numbers. To conclude, infection with <em>S. mattheei</em> is particularly common in cattle and demonstrates a previously cryptic burden of bovine schistosomiasis. 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Revealing bovine schistosomiasis in Malawi: Connecting human and hybrid schistosomes within cattle
In Malawi, the putative origin of a newly described Schistosoma haematobium-mattheei hybrid human schistosome was assessed upon a seminal molecular parasitological survey of cattle. Using miracidia hatch test (MHT) and carcass inspection at slaughter, mean prevalence of bovine schistosomiasis was 49.1% (95% CI: 43.7–54.6%) and 10.3% (95% CI: 6.0–16.2%) respectively, though significant spatial heterogeneity was noted. Approximately 2.0% of infected cattle, and only those from Mangochi District, shed S. haematobium-mattheei and/or S. haematobium in faeces. To quantify schistosome (re)infection dynamics, where a S. haematobium-mattheei hybrid was present, we undertook a novel pilot GPS-datalogging sub-study within a specific herd of cattle (n = 8) on the Lake Malawi shoreline, alongside a praziquantel (40 mg/kg) treatment efficacy spot check. At sub-study baseline, all GPS-tagged cattle had proven daily water contact with the lake. Each animal was patently infected upon MHT, with older animals shedding less miracidia. At one month review, whilst parasitological cure was 100.0%, from six weeks onwards, (re)infection was first noted in the youngest animal. By three-month review, all animals were patently (re)infected though only miracidia of S. mattheei were recovered, albeit in much lower numbers. To conclude, infection with S. mattheei is particularly common in cattle and demonstrates a previously cryptic burden of bovine schistosomiasis. Within Mangochi District, bovine transmission of both S. haematobium-mattheei hybrids and S. haematobium are now incriminated, with unequivocal evidence of contemporary zoonotic spill-over. Future control of urogenital schistosomiasis here in the southern region needs to develop, then successfully integrate, a One Health approach with appropriate mitigating strategies to reduce and/or contain bovine schistosomiasis transmission.
期刊介绍:
One Health - a Gold Open Access journal.
The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information.
Submissions to the following categories are welcome:
Virology,
Bacteriology,
Parasitology,
Mycology,
Vectors and vector-borne diseases,
Co-infections and co-morbidities,
Disease spatial surveillance,
Modelling,
Tropical Health,
Discovery,
Ecosystem Health,
Public Health.