紫外线老化微塑料与细胞损伤:体外研究

IF 3.7 4区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Archives of Environmental Contamination and Toxicology Pub Date : 2024-06-19 DOI:10.1007/s00244-024-01073-x
Sebastiano La Maestra, Mirko Benvenuti, Stefano Alberti, Linda Ferrea, Francesco D’Agostini
{"title":"紫外线老化微塑料与细胞损伤:体外研究","authors":"Sebastiano La Maestra,&nbsp;Mirko Benvenuti,&nbsp;Stefano Alberti,&nbsp;Linda Ferrea,&nbsp;Francesco D’Agostini","doi":"10.1007/s00244-024-01073-x","DOIUrl":null,"url":null,"abstract":"<div><p>Plastics are synthetic organic compounds whose widespread use generates enormous waste. Different processes, such as mechanical abrasion, microbiological activity, and UVB irradiation, can fragment the plastic material and generate microplastics (MPs). MPs are ubiquitous, and various organisms, including humans, can ingest or inhale them, with potential adverse health effects. The differences between UV-aged and virgin particles were studied to evaluate the genotoxic damage and oxidative stress induced by polystyrene MPs with 1 and 5 µm sizes on the monocyte-like cell line (THP-1). Fourier transform infrared spectroscopy and Ζ-potential measurements were used to characterise MP particles after UVB exposure. Cells exposed to MPs show a widespread change in the cellular environment with the generation of reactive oxidative species (ROS), as indicated by the increased malondialdehyde level. The occurrence of genotoxic damage is correlated to the smaller size and ageing state of the MPs. The biochemical and genomic alterations observed in this in vitro study suggest that MPs, ubiquitous pollutants, following natural degradation and oxidation processes can cause various adverse effects on the health of the exposed population, making it necessary to carry out further studies to better define the real risk.</p></div>","PeriodicalId":8377,"journal":{"name":"Archives of Environmental Contamination and Toxicology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283437/pdf/","citationCount":"0","resultStr":"{\"title\":\"UVB-Aged Microplastics and Cellular Damage: An in Vitro Study\",\"authors\":\"Sebastiano La Maestra,&nbsp;Mirko Benvenuti,&nbsp;Stefano Alberti,&nbsp;Linda Ferrea,&nbsp;Francesco D’Agostini\",\"doi\":\"10.1007/s00244-024-01073-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Plastics are synthetic organic compounds whose widespread use generates enormous waste. Different processes, such as mechanical abrasion, microbiological activity, and UVB irradiation, can fragment the plastic material and generate microplastics (MPs). MPs are ubiquitous, and various organisms, including humans, can ingest or inhale them, with potential adverse health effects. The differences between UV-aged and virgin particles were studied to evaluate the genotoxic damage and oxidative stress induced by polystyrene MPs with 1 and 5 µm sizes on the monocyte-like cell line (THP-1). Fourier transform infrared spectroscopy and Ζ-potential measurements were used to characterise MP particles after UVB exposure. Cells exposed to MPs show a widespread change in the cellular environment with the generation of reactive oxidative species (ROS), as indicated by the increased malondialdehyde level. The occurrence of genotoxic damage is correlated to the smaller size and ageing state of the MPs. The biochemical and genomic alterations observed in this in vitro study suggest that MPs, ubiquitous pollutants, following natural degradation and oxidation processes can cause various adverse effects on the health of the exposed population, making it necessary to carry out further studies to better define the real risk.</p></div>\",\"PeriodicalId\":8377,\"journal\":{\"name\":\"Archives of Environmental Contamination and Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283437/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Environmental Contamination and Toxicology\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00244-024-01073-x\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Environmental Contamination and Toxicology","FirstCategoryId":"93","ListUrlMain":"https://link.springer.com/article/10.1007/s00244-024-01073-x","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

塑料是一种合成有机化合物,其广泛使用会产生大量垃圾。不同的加工过程,如机械磨损、微生物活动和紫外线照射,都会使塑料材料破碎并产生微塑料(MPs)。微塑料无处不在,包括人类在内的各种生物都可能摄入或吸入微塑料,从而对健康造成潜在的不良影响。研究人员对紫外线老化颗粒和原始颗粒之间的差异进行了研究,以评估 1 微米和 5 微米大小的聚苯乙烯微塑料对单核细胞样细胞系(THP-1)诱导的基因毒性损伤和氧化应激。傅立叶变换红外光谱法和Ζ电位测量法用于描述紫外线照射后 MP 粒子的特征。暴露于 MPs 的细胞显示出细胞环境的广泛变化,产生了活性氧化物(ROS),丙二醛含量的增加就表明了这一点。基因毒性损伤的发生与 MPs 较小的尺寸和老化状态有关。在这项体外研究中观察到的生化和基因组变化表明,MPs 作为无处不在的污染物,经过自然降解和氧化过程后,会对暴露人群的健康造成各种不利影响,因此有必要开展进一步研究,以更好地确定实际风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
UVB-Aged Microplastics and Cellular Damage: An in Vitro Study

Plastics are synthetic organic compounds whose widespread use generates enormous waste. Different processes, such as mechanical abrasion, microbiological activity, and UVB irradiation, can fragment the plastic material and generate microplastics (MPs). MPs are ubiquitous, and various organisms, including humans, can ingest or inhale them, with potential adverse health effects. The differences between UV-aged and virgin particles were studied to evaluate the genotoxic damage and oxidative stress induced by polystyrene MPs with 1 and 5 µm sizes on the monocyte-like cell line (THP-1). Fourier transform infrared spectroscopy and Ζ-potential measurements were used to characterise MP particles after UVB exposure. Cells exposed to MPs show a widespread change in the cellular environment with the generation of reactive oxidative species (ROS), as indicated by the increased malondialdehyde level. The occurrence of genotoxic damage is correlated to the smaller size and ageing state of the MPs. The biochemical and genomic alterations observed in this in vitro study suggest that MPs, ubiquitous pollutants, following natural degradation and oxidation processes can cause various adverse effects on the health of the exposed population, making it necessary to carry out further studies to better define the real risk.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.00
自引率
2.50%
发文量
63
审稿时长
8-16 weeks
期刊介绍: Archives of Environmental Contamination and Toxicology provides a place for the publication of timely, detailed, and definitive scientific studies pertaining to the source, transport, fate and / or effects of contaminants in the environment. The journal will consider submissions dealing with new analytical and toxicological techniques that advance our understanding of the source, transport, fate and / or effects of contaminants in the environment. AECT will now consider mini-reviews (where length including references is less than 5,000 words), which highlight case studies, a geographic topic of interest, or a timely subject of debate. AECT will also consider Special Issues on subjects of broad interest. The journal strongly encourages authors to ensure that their submission places a strong emphasis on ecosystem processes; submissions limited to technical aspects of such areas as toxicity testing for single chemicals, wastewater effluent characterization, human occupation exposure, or agricultural phytotoxicity are unlikely to be considered.
期刊最新文献
Granulometric and Geochemical Distribution of Arsenic in a Mining Environmental Liability in a Semi-arid Area. Determining the Exposure Routes and Risk Assessment of Isocyanates in Indoor Environments. Radionuclides' Dispersion from Coal-Fired Brick Kilns: Geo-Environmental Processes, Potential Risks and Management. Examining Bald Eagle Contaminant Exposure and Reproductive Risk Above and Below Dams on Great Lakes Tributaries. Role of Organic Fertilizer in the Transfer of Lead to Vegetables Produced in Tropical Mountain Agroecosystems.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1