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引用次数: 0
摘要
肌肉疏松症会对癌症患者的生存产生负面影响。本研究旨在探讨肌肉疏松症与膀胱癌（BC）患者术后生存期及并发症的相关性。本研究检索了截至 2023 年 4 月 7 日的 Web of Science、Cochrane Library、Embase 和 PubMed 数据库，以收集有关肌肉疏松症对成年 BC 患者预后影响的研究。主要结果包括总生存期（OS）、癌症特异性生存期（CSS）和无复发生存期（RFS）。次要结果包括术后并发症。使用 Stata 进行了荟萃分析。采用森林图和摘要效应模型来呈现结果。采用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale，NOS）对符合条件的研究进行质量评估。通过在四个数据库中搜索，初步确定了 1713 项研究，最终有 26 项研究被纳入分析。在 BC 患者中，肌肉疏松症与 OS（HR：1.62；95% CI：1.43-1.83；P I2 = 0.9%）、CSS（HR：1.81；95% CI：1.52-2.15；P I2 = 0.0%）和 RFS（HR：1.76；95% CI：1.21-2.56；P = 0.003；I2 = 0.0%）明显相关。亚组分析显示，肌少症与 BC 患者的预后和术后并发症密切相关。
Prognostic Effects of Sarcopenia on Patients with Bladder Cancer: A Systematic Review and Meta-Analysis.
Sarcopenia can negatively impact the survival of cancer patients. This study intends to delve into the correlation of sarcopenia with survival and complications in patients with bladder cancer (BC) after surgery. Web of Science, Cochrane Library, Embase, and PubMed databases were retrieved up to April 7, 2023, to collect studies on the impact of sarcopenia on the prognosis of adults with BC. Primary outcomes encompassed overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS). The secondary outcome consisted of postoperative complications. A meta-analysis was conducted using Stata. Forest plots and summary effect models were employed to present the results. The quality of eligible studies was assessed using the Newcastle-Ottawa Scale (NOS). Initially, 1713 studies were identified through searches across four databases, and 26 studies were ultimately included in the analysis. Sarcopenia was significantly associated with OS (HR:1.62; 95% CI: 1.43-1.83; P < 0.001, I2 = 0.9%), CSS (HR: 1.81, 95% CI: 1.52-2.15, P < 0.001, I2 = 0.0%), and RFS (HR: 1.76, 95% CI: 1.21-2.56, P = 0.003, I2 = 0.0%) in BC patients. Subgroup analyses revealed that sarcopenia is strongly linked to prognosis and postoperative complications in BC patients.
期刊介绍：
Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.
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