Ceftaroline in CNS and ocular infections: a case series.

Background: There are limited data describing outcomes of patients treated with ceftaroline for infections with CNS or ocular involvement.

Objectives: To describe outcomes of patients treated with ceftaroline for methicillin-resistant staphylococcal infections involving the CNS or eye.

Patients and methods: This was a retrospective review of 10 patients at an academic medical centre who received ceftaroline for CNS or ocular infections.

Results: All patients were treated with ceftaroline as part of a combination for salvage therapy. Four patients died, whereas six patients experienced clinical cure. Only one experienced microbiological recurrence.

Conclusions: These preliminary data suggest that ceftaroline may be an option for salvage therapy of severe staphylococcal infections when used in combination.