立体定向放射治疗与分次放射治疗在 44 只垂体肿块犬中的疗效:一项多机构回顾性研究(2016-2022年)》。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-09-01 Epub Date: 2024-06-18 DOI:10.1111/vco.12991
Tracy L Gieger, Leanne Magestro, Jillian Walz, Hiroto Yoshikawa, Michael W Nolan
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引用次数: 0

摘要

尽管犬垂体肿块(PM)越来越多地采用立体定向放射治疗(SRT),但历史文献资料显示,传统的全疗程分次放射治疗(FRT)疗效更佳。我们开展了一项多机构回顾性研究,研究对象包括2016年至2022年期间接受SRT(总剂量30或35 Gy,每天5次分次放疗)或FRT(总剂量50-54 Gy,每天19-20次分次放疗)治疗的垂体瘤犬。评估了潜在预后/预测因素的影响,包括垂体:脑高、垂体:脑容量、性别、年龄和内分泌状态(功能性 [F] PM 与非功能性 [NF] PM)。共纳入了 44 只患有 PM 的狗(26 只 F 型,14 只 NF 型,4 只未知)。所有患者都按计划完成了治疗方案(SRT = 27,FRT = 17),有两只狗出现了疑似一级急性神经毒性。在 RT 治疗后的前 6 个月中,5/27(19%)只接受 SRT 治疗的狗(4 只 F,1 只 NF)和 3/17(18%)只接受 FRT 治疗的狗(均为 F)因出现进行性神经症状而死亡或安乐死。总体中位生存时间为 608 天(95% CI,375-840 天)。接受治疗时年龄较小对存活率有显著影响(p = 0.0288);狗的总存活时间中位数为 753 天。
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Outcomes of Stereotactic Radiation Therapy Versus Fractionated Radiation Therapy in 44 Dogs With Pituitary Masses: A Multi-Institutional Retrospective Study (2016-2022).

Although canine pituitary masses (PM) are increasingly treated with stereotactic radiotherapy (SRT), historical literature supports superior outcomes with conventional full-course fractionated radiation therapy (FRT). A multi-institutional retrospective study was performed, including dogs with PM treated from 2016 to 2022 with SRT (total dose 30 or 35 Gy in 5 daily fractions) or FRT (total dose 50-54 Gy in 19-20 daily fractions). The influence of potential prognostic/predictive factors was assessed, including pituitary: brain height, pituitary: brain volume, sex, age and endocrine status (functional [F] vs. nonfunctional [NF] PM). Forty-four dogs with PM were included (26 F, 14 NF, 4 unknown). All patients completed protocols as scheduled (SRT = 27, FRT = 17) and two dogs had suspected Grade 1 acute neurotoxicity. During the first 6 months after RT, 5/27 (19%) dogs treated with SRT (4 F, 1 NF) and 3/17 (18%) dogs treated with FRT (all F) died or were euthanised because of progressive neurologic signs. The overall median survival time was 608 days (95% CI, 375-840 days). Young age at the time of treatment was significant for survival (p = 0.0288); the overall median survival time was 753 days for dogs <9 years of age (95% CI, 614-892 days) and 445 days for dogs ≥9 years of age (95% CI, 183-707 days). Survival time was not associated with treatment type or any other factor assessed herein. A prospective study using standardised protocols would further validate the results of the present study and potentially elucidate the predictors of early death.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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