幽门螺杆菌通过扰乱免疫微环境引发炎症和致癌转化

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-17 DOI:10.1016/j.bbcan.2024.189139
Xiuping Wang , Guang Zhao , Shihe Shao , Yongliang Yao
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引用次数: 0

摘要

免疫微环境在幽门螺杆菌(H. pylori)的发病机制中起着关键的调节作用。了解从慢性炎症向癌症过渡的驱动机制可能会为早期检测胃癌提供新的见解。虽然慢性炎症在胃癌前病变中很常见,但炎症微环境在幽门螺杆菌诱导的慢性炎症向胃癌发展过程中的监测功能仍不清楚。本文献综述总结了有关幽门螺杆菌如何通过免疫微环境引发炎症反应并促进癌症发展的重要发现。此外,还探讨了对未来研究和临床应用的影响。综述分为四个主要部分:幽门螺杆菌诱导的炎症反应和免疫逃避机制、与胃癌相关的免疫失调、治疗意义以及对幽门螺杆菌诱导胃癌发生的未来展望,重点关注免疫微环境。
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Helicobacter pylori triggers inflammation and oncogenic transformation by perturbing the immune microenvironment

The immune microenvironment plays a critical regulatory role in the pathogenesis of Helicobacter pylori (H. pylori). Understanding the mechanisms that drive the transition from chronic inflammation to cancer may provide new insights for early detection of gastric cancer. Although chronic inflammation is frequent in precancerous gastric conditions, the monitoring function of the inflammatory microenvironment in the progression from H. pylori-induced chronic inflammation to gastric cancer remains unclear. This literature review summarizes significant findings on how H. pylori triggers inflammatory responses and facilitates cancer development through the immune microenvironment. Furthermore, the implications for future research and clinical applications are also addressed. The review is divided into four main sections: inflammatory response and immune evasion mechanisms induced by H. pylori, immune dysregulation associated with gastric cancer, therapeutic implications, and future perspectives on H. pylori-induced gastric carcinogenesis with a focus on the immune microenvironment.

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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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