代谢性疾病中的组织驻留细菌:新证据与挑战

IF 18.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nature metabolism Pub Date : 2024-06-19 DOI:10.1038/s42255-024-01065-0
Lucas Massier, Niculina Musat, Michael Stumvoll, Valentina Tremaroli, Rima Chakaroun, Peter Kovacs
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引用次数: 0

摘要

虽然肠道微生物组对健康和疾病的影响已得到公认,但对于器官和组织中是否存在细菌等微生物及其产物还存在争议。不过,最近对组织驻留微生物特征的污染意识研究结果提供了越来越多的证据,支持细菌在心脏代谢疾病中的转移。后者为粘膜表面微生物定植者与宿主新陈代谢之间的联系提供了一个独特的范例。在本《视角》中,我们重新评估了组织驻留细菌的概念,包括它们在低级组织代谢和全身炎症中的作用。我们研究了与研究低细菌生物量样本相关的局限性和挑战,并提出了克服这些问题的实验和分析策略。我们的视角旨在鼓励进一步研究组织驻留细菌与宿主新陈代谢之间的关联机制及其对预防和治疗的潜在健康影响。
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Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges
Although the impact of the gut microbiome on health and disease is well established, there is controversy regarding the presence of microorganisms such as bacteria and their products in organs and tissues. However, recent contamination-aware findings of tissue-resident microbial signatures provide accumulating evidence in support of bacterial translocation in cardiometabolic disease. The latter provides a distinct paradigm for the link between microbial colonizers of mucosal surfaces and host metabolism. In this Perspective, we re-evaluate the concept of tissue-resident bacteria including their role in metabolic low-grade tissue and systemic inflammation. We examine the limitations and challenges associated with studying low bacterial biomass samples and propose experimental and analytical strategies to overcome these issues. Our Perspective aims to encourage further investigation of the mechanisms linking tissue-resident bacteria to host metabolism and their potentially actionable health implications for prevention and treatment. In this Perspective, the role of tissue-resident bacteria in metabolic diseases is discussed and the experimental challenges that this emerging field is facing are highlighted.
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来源期刊
Nature metabolism
Nature metabolism ENDOCRINOLOGY & METABOLISM-
CiteScore
27.50
自引率
2.40%
发文量
170
期刊介绍: Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.
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