从普遍性到特异性:细菌硫氧还蛋白系统的多种功能。

IF 4.3 2区 生物学 Q2 MICROBIOLOGY Environmental microbiology Pub Date : 2024-06-20 DOI:10.1111/1462-2920.16668
Cyril Anjou, Aurélie Lotoux, Claire Morvan, Isabelle Martin-Verstraete
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引用次数: 0

摘要

普遍存在的硫氧还蛋白(Trx)系统负责活细胞中可逆氧化蛋白质硫醇的再生。该系统由一个 Trx 和一个 Trx 还原酶组成,通过还原氧化的蛋白质硫醇(如蛋白质中的二硫键),在维持以硫醇为基础的氧化还原平衡方面发挥着核心作用。除了硫醇-二硫还原酶活性外,一些 Trx 还具有独立于硫醇-二硫交换的伴侣功能。Trx 系统的这两种活性参与了细菌的许多生理过程。本综述介绍了在细菌进化过程中出现的 Trx 系统的各种生理作用。Trx 系统对于应对氧化和亚硝基压力至关重要。除了这一主要功能外,Trx 系统还参与氧化还原调节和信号转导,以及控制新陈代谢、运动、生物膜形成和毒力。这一系列功能是随着细菌生活方式的多样性及其特定的限制因素而进化的。这种进化的特点是系统的倍增和辅助因子或目标的专业化,以适应非典型生活方式的限制,如光合作用、昆虫内共生或孢子形成细菌。
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From ubiquity to specificity: The diverse functions of bacterial thioredoxin systems

The thioredoxin (Trx) system, found universally, is responsible for the regeneration of reversibly oxidized protein thiols in living cells. This system is made up of a Trx and a Trx reductase, and it plays a central role in maintaining thiol-based redox homeostasis by reducing oxidized protein thiols, such as disulfide bonds in proteins. Some Trxs also possess a chaperone function that is independent of thiol-disulfide exchange, in addition to their thiol-disulfide reductase activity. These two activities of the Trx system are involved in numerous physiological processes in bacteria. This review describes the diverse physiological roles of the Trx system that have emerged throughout bacterial evolution. The Trx system is essential for responding to oxidative and nitrosative stress. Beyond this primary function, the Trx system also participates in redox regulation and signal transduction, and in controlling metabolism, motility, biofilm formation, and virulence. This range of functions has evolved alongside the diversity of bacterial lifestyles and their specific constraints. This evolution can be characterized by the multiplication of the systems and by the specialization of cofactors or targets to adapt to the constraints of atypical lifestyles, such as photosynthesis, insect endosymbiosis, or spore-forming bacteria.

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来源期刊
Environmental microbiology
Environmental microbiology 环境科学-微生物学
CiteScore
9.90
自引率
3.90%
发文量
427
审稿时长
2.3 months
期刊介绍: Environmental Microbiology provides a high profile vehicle for publication of the most innovative, original and rigorous research in the field. The scope of the Journal encompasses the diversity of current research on microbial processes in the environment, microbial communities, interactions and evolution and includes, but is not limited to, the following: the structure, activities and communal behaviour of microbial communities microbial community genetics and evolutionary processes microbial symbioses, microbial interactions and interactions with plants, animals and abiotic factors microbes in the tree of life, microbial diversification and evolution population biology and clonal structure microbial metabolic and structural diversity microbial physiology, growth and survival microbes and surfaces, adhesion and biofouling responses to environmental signals and stress factors modelling and theory development pollution microbiology extremophiles and life in extreme and unusual little-explored habitats element cycles and biogeochemical processes, primary and secondary production microbes in a changing world, microbially-influenced global changes evolution and diversity of archaeal and bacterial viruses new technological developments in microbial ecology and evolution, in particular for the study of activities of microbial communities, non-culturable microorganisms and emerging pathogens
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