Ali Alizadeh Khatir, Fariborz Mousavi, Mahdi Sepidarkish, Mahdi Arshadi, Delaram Arjmandi, Maryam Aldaghi, Ali Rostami
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引用次数: 0
摘要
背景：感染可能导致阿尔茨海默病（AD）风险。有限的证据表明，弓形虫感染/接触可能会影响阿尔茨海默病的发展：我们通过一项匹配的病例对照研究调查了伊朗成年人的弓形虫血清阳性率和阿兹海默症。我们的样本包括 90 例 AD 病例和 91 例健康老年人。抗弓形虫免疫球蛋白 G (IgG) 抗体通过酶联免疫吸附试验进行评估。我们通过单变量和多变量分析计算了几率比（ORs）和95%置信区间（CIs），并对潜在的混杂因素进行了调整：在AD病例中发现了33/90（36.67% [95% CI 26.75 to 47.48]）名抗弓形虫IgG血清阳性者，在健康对照组中发现了21/91（23.07% [95% CI 14.89 to 33.09]）名抗弓形虫IgG血清阳性者。在单变量分析中，抗弓形虫 IgG 血清阳性与 AD 之间存在显著关联（OR 1.93 [95% CI 1.01 至 3.69]，p 结论：我们的研究结果表明，弓形虫暴露/感染可能是诱发AD的潜在风险因素。为了更好地了解弓形虫暴露/感染与AD及相关痴呆症之间的真正因果关系，需要进行后续设计和充分的研究。
Association between Alzheimer's disease and Toxocara infection/exposure: a case-control study.
Background: Infections may contribute to Alzheimer's disease (AD) risk. Limited evidence suggests Toxocara spp. infection/exposure could influence AD development.
Methods: We investigated Toxocara seropositivity and AD in Iranian adults using a matched case-control study. Our sample included 90 AD cases and 91 healthy older adults. Anti-Toxocara immunoglobulin G (IgG) antibodies were assessed via enzyme-linked immunosorbent assay. We computed the odds ratios (ORs) and 95% confidence intervals (CIs) through univariable and multivariable analyses, adjusting for potential confounders.
Results: There were 33/90 (36.67% [95% CI 26.75 to 47.48]) anti-Toxocara IgG seropositive individuals identified among the AD cases and 21/91 (23.07% [95% CI 14.89 to 33.09]) among the healthy controls. In univariable analysis, a significant association was identified between anti-Toxocara IgG seropositivity and AD (OR 1.93 [95% CI 1.01 to 3.69], p<0.001). Moreover, the association remained significant (OR 2.18 [95% CI 1.05 to 4.49], p<0.001) in multivariable analysis after adjustment for covariates. There was no association between anti-Toxocara IgG seropositivity and the severity of AD (OR 0.75 [95% CI 0.21 to 2.61], p=0.47).
Conclusions: Our findings indicated that Toxocara exposure/infection could be a potential risk factor for development of AD. To better understand a real causality between Toxocara exposure/infection and AD and related dementias, follow-up designed and adequately powered studies are needed.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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