基于 Bis-EFMA 的低收缩散装填充牙科树脂复合材料的性能。

IF 4.6 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Dental Materials Pub Date : 2024-06-20 DOI:10.1016/j.dental.2024.06.025

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引用次数: 0

摘要

研究目的本研究的目的是评估基于 Bis-EFMA 的新型填充复合材料与基于普通甲基丙烯酸酯的复合材料和商用牙科复合材料的性能：合成了双-EFMA单体，并制备了新型双-EFMA基填充复合材料。用人牙龈上皮细胞和人牙髓干细胞共同培养树脂复合材料样品，以测试其生物相容性。在立体镜和扫描电子显微镜下观察边缘适应性。使用维氏硬度计测量了一次性填充拔牙龋洞后的内部硬度。在对树脂复合材料表面进行摩擦和磨损测试后，用光学轮廓仪测量了各组的表面形态和体积磨损。用色度计测量颜色稳定性：与人牙龈上皮细胞和人牙髓干细胞直接接触不会导致其生长密度和形态发生显著变化，这表明双-EFMA 组具有良好的生物相容性（p > 0.05）。Bis-EFMA 组的连续边缘比例与商业填充复合材料相当（p > 0.05）。断面显微硬度结果显示，Bis-EFMA 组的显微硬度最高。经过摩擦磨损测试，Bis-EFMA 组的体积磨损极小，表明其具有良好的耐磨性和机械强度。浸泡 28 天后，所有树脂组的颜色变化都在临床可接受的范围内：加入 Bis-EFMA 后，其生物相容性、边缘适应性和颜色稳定性都非常出色，可与临床常用的散装填充复合材料媲美，同时机械强度、摩擦性和耐磨性也更佳。基于 Bis-EFMA 的块状填充复合材料有可能被用作商业牙科复合材料应用中的块状填充材料。

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Performance of low shrinkage Bis-EFMA based bulk-fill dental resin composites

Objectives

The purpose of this study was evaluating the performance of new Bis-EFMA based bulk-fill composites with common methacrylate based composites and commercial dental composites.

Methods

The Bis-EFMA monomer was synthesized and the novel Bis-EFMA based bulk-fill composites were prepared. The resin composite samples were co-cultured with human gingival epithelial cells and human dental pulp stem cells to test the biocompatibility. The edge adaptation was observed under a combination of stereoscope and scanning electron microscope. The internal hardness was measured using a Vickers microhardness tester after one-time filling of cavities prepared in extracted teeth. After friction and wear test on the surface of the resin composites, the surface morphology and volume wear of each group were measured by the optical profilometer. The color stability was measured by a colorimeter.

Results

Direct contact with human gingival epithelial cells and human dental pulp stem cells did not cause significant changes in their growth density and morphology, indicating good biocompatibility of Bis-EFMA group (p > 0.05). The continuous margin proportion of the Bis-EFMA group was as good as commercial bulk-fill composites (p > 0.05). The sectional microhardness results showed that the Bis-EFMA group had the highest microhardness. After the friction and wear test, the volume wear of the Bis-EFMA group was minimal, indicating its good wear resistance and mechanical strength. Color changes in all resin groups after 28 days of immersion were within the clinically acceptable range.

Significance

The addition of Bis-EFMA demonstrated excellent biocompatibility, edge adaptation and color stability comparable to commonly used clinical bulk-fill composites, along with preferable mechanical strength, friction and wear resistance. Bis-EFMA based bulk-fill composites have the potential to be employed as a bulk filling material in commercial dental composite applications.

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.