针对咳嗽受体的药物:难治性或不明原因慢性咳嗽的新疗法。

IF 13 1区 医学 Q1 PHARMACOLOGY & PHARMACY Drugs Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI:10.1007/s40265-024-02047-y
Laurent Guilleminault, Stanislas Grassin-Delyle, Stuart B Mazzone
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引用次数: 0

摘要

难治性慢性咳嗽是一种致残性疾病,治疗方法非常有限。随着人们对咳嗽病理生理学的深入了解,以咳嗽受体为靶点的新型药物应运而生。最近的进展阐明了新的治疗途径,主要集中在调节瞬时受体电位(TRP)通道、嘌呤能受体和神经激肽受体。通过调节这些受体,目的是干预引发咳嗽反射的感觉通路,从而在不损害重要保护机制的情况下缓解咳嗽。这些创新的药物疗法有望改善难治性慢性咳嗽,提高疗效,并有可能减轻与当前推荐疗法相关的不良反应。深入了解这些药物的确切作用机制和临床可行性,对于优化治疗干预措施和提高呼吸健康领域的患者护理标准至关重要。本综述描述了这一领域药物开发的演变情况,强调了这些进展在重塑咳嗽治疗模式方面的重要意义。
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Drugs Targeting Cough Receptors: New Therapeutic Options in Refractory or Unexplained Chronic Cough.

Refractory chronic cough is a disabling disease with very limited therapeutic options. A better understanding of cough pathophysiology has led to the development of emerging drugs targeting cough receptors. Recent strides have illuminated novel therapeutic avenues, notably centred on modulating transient receptor potential (TRP) channels, purinergic receptors, and neurokinin receptors. By modulating these receptors, the goal is to intervene in the sensory pathways that trigger cough reflexes, thereby providing relief without compromising vital protective mechanisms. These innovative pharmacotherapies hold promise for improvement of refractory chronic cough by offering improved efficacy and potentially mitigating adverse effects associated with current recommended treatments. A deeper comprehension of their precise mechanisms of action and clinical viability is imperative for optimising therapeutic interventions and elevating patient care standards in respiratory health. This review delineates the evolving landscape of drug development in this domain, emphasising the significance of these advancements in reshaping the paradigm of cough management.

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来源期刊
Drugs
Drugs 医学-毒理学
CiteScore
22.70
自引率
0.90%
发文量
134
审稿时长
3-8 weeks
期刊介绍: Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.
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