索泰瑞普：首次批准。

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY Drugs Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI:10.1007/s40265-024-02058-9

Connie Kang

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引用次数: 0

摘要

Sotatercept（sotatercept-csrk；WINREVAIRTM）是一种激活素信号抑制剂，由默克公司（Rahway, NJ, USA）开发，用于治疗肺动脉高压。Sotatercept 最近在美国获得批准，用于治疗成人肺动脉高压患者（世界卫生组织（WHO）第 1 组），以提高运动能力、改善 WHO 功能分级并降低临床恶化事件的风险。本文总结了索泰特受体（sotatercept）开发过程中的里程碑事件，这些事件促成了索泰特受体（sotatercept）首次获准用于治疗肺动脉高压。

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Sotatercept: First Approval.

Sotatercept (sotatercept-csrk; WINREVAIR^TM) is an activin signalling inhibitor that is being developed by Merck and Co., Inc. (Rahway, NJ, USA) for the treatment of pulmonary arterial hypertension. Sotatercept recently received approval in the USA for the treatment of adults with pulmonary arterial hypertension [World Health Organisation (WHO) Group 1] to increase exercise capacity, improve WHO functional class and reduce the risk of clinical worsening events. This article summarizes the milestones in the development of sotatercept leading to this first approval for pulmonary arterial hypertension.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.