急性慢性肝功能衰竭患者肝移植结果的供体年龄影响:队列研究

IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Gut and Liver Pub Date : 2024-06-21 DOI:10.5009/gnl230143
Jie Zhou, Danni Ye, Shenli Ren, Jiawei Ding, Tao Zhang, Siyao Zhang, Zheng Chen, Fangshen Xu, Yu Zhang, Huilin Zheng, Zhenhua Hu
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引用次数: 0

摘要

背景/目的:肝移植是急性慢性肝功能衰竭(ACLF)重症患者最有效的治疗方法。然而,供体年龄对肝移植的影响,尤其是对 ACLF 患者的影响仍不清楚:在这项研究中,我们使用了移植受者科学登记处的数据。我们纳入了从 2007 年 1 月 1 日至 2017 年 12 月 31 日接受肝移植的 ACLF 患者,总人数为 13857 人。我们将ACLF受者按年龄分为I组(供体年龄≤17岁,n=647)、II组(供体年龄18-59岁,n=11423)和III组(供体年龄≥60岁,n=1787)。比较了三个年龄组和四个 ACLF 等级的总存活率(OS)、移植物存活率和死亡率。同时还进行了Cox回归分析:结果:I组的1年、3年和5年OS率分别为89.6%、85.5%和82.0%;II组分别为89.4%、83.4%和78.2%;III组分别为86.8%、78.4%和71.4%(P结论:供体年龄与 ACLF 患者移植后的操作系统和移植物存活率有关,老年供体的结果较差。此外,不同的供体年龄对不同分级的 ACLF 受体有不同的影响。
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Impact of Donor Age on Liver Transplant Outcomes in Patients with Acute-on-Chronic Liver Failure: A Cohort Study.

Background/aims: Liver transplantation is the most effective treatment for the sickest patients with acute-on-chronic liver failure (ACLF). However, the influence of donor age on liver transplantation, especially in ACLF patients, is still unclear.

Methods: In this study, we used the data of the Scientific Registry of Transplant Recipients. We included patients with ACLF who received liver transplantation from January 1, 2007, to December 31, 2017, and the total number was 13,857. We allocated the ACLF recipients by age into group I (donor age ≤17 years, n=647); group II (donor age 18-59 years, n=11,423); and group III (donor age ≥60 years, n=1,787). Overall survival (OS), graft survival, and mortality were compared among the three age groups and the four ACLF grades. Cox regression was also analyzed.

Results: The 1-, 3-, and 5-year OS rates were 89.6%, 85.5%, and 82.0% in group I; 89.4%, 83.4%, and 78.2% in group II; and 86.8%, 78.4%, and 71.4% in group III, respectively (p<0.001). When we analyzed the different effects of donor age on OS with different ACLF grades, in groups II and III, we observed statistical differences. Finally, the cubic spline curve told us that the relative death rate changed linearly with increasing donor age.

Conclusions: Donor age is related to OS and graft survival of ACLF patients after transplantation, and poorer results were associated with elderly donors. In addition, different donor ages have different effects on recipients with different ACLF grades.

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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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