{"title":"注意缺陷多动障碍(ADHD)儿童体内的维生素 B9 和 B12。","authors":"Fatemeh Razavinia, Atefeh Ebrahimiyan, Shahla Faal Siahkal, Neda Ghazinezhad, Parvin Abedi","doi":"10.1024/0300-9831/a000809","DOIUrl":null,"url":null,"abstract":"<p><p><b></b> <i>Background:</i> Attention deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder that begins before age 12. Given the role of B group vitamins in cell metabolism, synthesis of nucleotides, and neurotransmitters, the present study systematically investigated the plasma levels of vitamins B<sub>9</sub> and B<sub>12</sub> in children with ADHD. <i>Methods:</i> We searched electronic databases including Web of Science, MEDLINE, EMBASE, Scopus, Iran MEDEX, Cochran database, and SID from conception to June 2023. Full-text case-control or cross-sectional studies were included in this study. Participants in the case group were children with ADHD aged 6-12 years. Review Manager Software (RevMan 5.4) was used for statistical analyses. Standardized mean differences (SMD) with 95% CIs were used to determine the differences between the two groups. <i>Results:</i> Six studies were included in the present meta-analysis. They included 982 children, of whom, 204 were girls and 744 were boys. The mean age of the children was 8.86±2.03 years. The level of vitamin B<sub>9</sub> was significantly different between children with and without ADHD [SMD -0.80, 95% CI (-1.55, -0.04)]. Vitamin B<sub>12</sub> was significantly lower in children with ADHD [SMD -0.29, 95% CI (-0.42, -0.16)]. However, due to high heterogeneity (I<sup>2</sup> = 93%), sensitivity analysis was used, I<sup>2</sup> fell to 21%, and significant difference was observed between the two groups [SMD -0.19, 95% CI (-0.34, -0.04)]. <i>Conclusion:</i> The results of this systematic review showed that the level of vitamins B<sub>9</sub> and B<sub>12</sub> in children with ADHD was significantly lower than that in healthy children.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"94 5-6","pages":"476-484"},"PeriodicalIF":2.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Vitamins B<sub>9</sub> and B<sub>12</sub> in children with attention deficit hyperactivity disorder (ADHD).\",\"authors\":\"Fatemeh Razavinia, Atefeh Ebrahimiyan, Shahla Faal Siahkal, Neda Ghazinezhad, Parvin Abedi\",\"doi\":\"10.1024/0300-9831/a000809\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b></b> <i>Background:</i> Attention deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder that begins before age 12. Given the role of B group vitamins in cell metabolism, synthesis of nucleotides, and neurotransmitters, the present study systematically investigated the plasma levels of vitamins B<sub>9</sub> and B<sub>12</sub> in children with ADHD. <i>Methods:</i> We searched electronic databases including Web of Science, MEDLINE, EMBASE, Scopus, Iran MEDEX, Cochran database, and SID from conception to June 2023. Full-text case-control or cross-sectional studies were included in this study. Participants in the case group were children with ADHD aged 6-12 years. Review Manager Software (RevMan 5.4) was used for statistical analyses. Standardized mean differences (SMD) with 95% CIs were used to determine the differences between the two groups. <i>Results:</i> Six studies were included in the present meta-analysis. They included 982 children, of whom, 204 were girls and 744 were boys. The mean age of the children was 8.86±2.03 years. The level of vitamin B<sub>9</sub> was significantly different between children with and without ADHD [SMD -0.80, 95% CI (-1.55, -0.04)]. Vitamin B<sub>12</sub> was significantly lower in children with ADHD [SMD -0.29, 95% CI (-0.42, -0.16)]. However, due to high heterogeneity (I<sup>2</sup> = 93%), sensitivity analysis was used, I<sup>2</sup> fell to 21%, and significant difference was observed between the two groups [SMD -0.19, 95% CI (-0.34, -0.04)]. <i>Conclusion:</i> The results of this systematic review showed that the level of vitamins B<sub>9</sub> and B<sub>12</sub> in children with ADHD was significantly lower than that in healthy children.</p>\",\"PeriodicalId\":13884,\"journal\":{\"name\":\"International Journal for Vitamin and Nutrition Research\",\"volume\":\"94 5-6\",\"pages\":\"476-484\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal for Vitamin and Nutrition Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1024/0300-9831/a000809\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal for Vitamin and Nutrition Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1024/0300-9831/a000809","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
背景介绍注意缺陷多动障碍(ADHD)是一种常见的儿童神经发育障碍,发病年龄在 12 岁之前。鉴于 B 族维生素在细胞代谢、核苷酸合成和神经递质中的作用,本研究系统地调查了注意力缺陷多动障碍儿童血浆中维生素 B9 和 B12 的水平。研究方法我们检索了自构想至 2023 年 6 月的电子数据库,包括 Web of Science、MEDLINE、EMBASE、Scopus、Iran MEDEX、Cochran 数据库和 SID。本研究纳入了全文病例对照或横断面研究。病例组的参与者为 6-12 岁患有多动症的儿童。统计分析使用的是综述管理软件(RevMan 5.4)。使用标准化平均差 (SMD) 和 95% CIs 来确定两组之间的差异。结果本荟萃分析共纳入六项研究。共纳入 982 名儿童,其中 204 名女孩,744 名男孩。儿童的平均年龄为(8.86±2.03)岁。有多动症和没有多动症的儿童的维生素B9水平有显著差异[SMD -0.80,95% CI (-1.55, -0.04)]。多动症儿童的维生素B12含量明显较低[SMD -0.29,95% CI (-0.42, -0.16)]。然而,由于异质性较高(I2 = 93%),使用敏感性分析后,I2 降至 21%,两组之间出现了显著差异[SMD -0.19,95% CI (-0.34, -0.04)]。结论本系统综述的结果显示,多动症儿童的维生素B9和B12水平明显低于健康儿童。
Vitamins B9 and B12 in children with attention deficit hyperactivity disorder (ADHD).
Background: Attention deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder that begins before age 12. Given the role of B group vitamins in cell metabolism, synthesis of nucleotides, and neurotransmitters, the present study systematically investigated the plasma levels of vitamins B9 and B12 in children with ADHD. Methods: We searched electronic databases including Web of Science, MEDLINE, EMBASE, Scopus, Iran MEDEX, Cochran database, and SID from conception to June 2023. Full-text case-control or cross-sectional studies were included in this study. Participants in the case group were children with ADHD aged 6-12 years. Review Manager Software (RevMan 5.4) was used for statistical analyses. Standardized mean differences (SMD) with 95% CIs were used to determine the differences between the two groups. Results: Six studies were included in the present meta-analysis. They included 982 children, of whom, 204 were girls and 744 were boys. The mean age of the children was 8.86±2.03 years. The level of vitamin B9 was significantly different between children with and without ADHD [SMD -0.80, 95% CI (-1.55, -0.04)]. Vitamin B12 was significantly lower in children with ADHD [SMD -0.29, 95% CI (-0.42, -0.16)]. However, due to high heterogeneity (I2 = 93%), sensitivity analysis was used, I2 fell to 21%, and significant difference was observed between the two groups [SMD -0.19, 95% CI (-0.34, -0.04)]. Conclusion: The results of this systematic review showed that the level of vitamins B9 and B12 in children with ADHD was significantly lower than that in healthy children.
期刊介绍:
Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds.
The editorial and advisory boards include many of the leading persons currently working in this area.
The journal is of particular interest to:
- Nutritionists
- Vitaminologists
- Biochemists
- Physicians
- Engineers of human and animal nutrition
- Food scientists