Moaz A Eltabeeb, Menna M Abdellatif, Mohamed A El-Nabarawi, Mahmoud H Teaima, Mohammed I A Hamed, Khaled M Darwish, Mariam Hassan, Ahmed Me Hamdan, Raghda Rabe Hamed
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引用次数: 0
摘要
目的：我们的调查旨在评估盐酸普萘洛尔（PNL）的抗真菌效果。方法：采用薄膜水合法制造油小体（OLs），并评估其抗真菌效果（单位：mg/g）：通过薄膜水合法制备油小体（OLs），并评估其包载效率（EE%）、粒度（PS）、多分散指数（PDI）、Zeta 电位（ZP）以及 6 小时 Q6h 后的药物释放量（%）。结果显示最佳 OL 呈圆形，具有最佳特性。体内外渗透和共聚焦激光扫描显微镜验证了负载 PNL 的 OLs-凝胶的长期释放和良好沉积。室内评估表明，PNL 与 OL 成分具有良好的稳定性。载入 PNL 的 OLs-凝胶的体内评估显示，它对白色念珠菌具有良好的抗真菌效果，而且安全性良好。结论这项研究强调了 PNL 负载 OLs-凝胶作为治疗念珠菌阴道感染的潜在药物的潜力。
Aim: Our investigation aims to estimate the antifungal effect of propranolol hydrochloride (PNL). Methods: Oleosomes (OLs) were fabricated by thin-film hydration and evaluated for entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and amount of drug released after 6 h Q6h (%). Results: The optimal OL showed a rounded shape with optimum characteristics. The ex-vivo permeation and confocal laser scanning microscopy verified the prolonged release and well deposition of PNL-loaded OLs-gel. The in-silico assessment demonstrated the good stability of PNL with OLs' ingredients. In vivo evaluations for PNL-loaded OLs-gel showed a good antifungal impact against Candida albicans with good safety. Conclusion: This work highlights the potential of PNL-loaded OLs-gel as a potential treatment for candida vaginal infection.
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