NICHE-2 验证了新辅助 ICIs 在 dMMR 结肠癌中的疗效

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-06-21 DOI:10.1038/s41571-024-00922-x
David Killock
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引用次数: 0

摘要

免疫检查点抑制剂(ICIs)彻底改变了晚期DNA错配修复缺陷(dMMR)结直肠癌的治疗方法。NICHE 试验揭示了 ICIs 作为局部晚期 dMMR 结肠癌患者新辅助疗法的前景,NICHE-2 II 期试验的新数据证实了这一策略的安全性和有效性。NICHE-2 试验涉及 115 例局部晚期 dMMR 结肠癌患者,其中高危 cT3-T4 肿瘤(85%)和/或 III 期、结节阳性疾病(67%)患者占多数。所有患者术前都接受了两次剂量为3毫克/千克的nivolumab治疗(第1天和第15天),第一次与伊匹单抗(1毫克/千克)联合使用。及时手术(入组后超过预设的6周,延迟时间≤2周)和3年无病生存期(DFS)是双重主要终点。
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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