Harish Palnitkar , Rolf Reiter , Shreyan Majumdar , Joseph Crutison , Shujun Lin , Thomas J. Royston , Dieter Klatt
{"title":"基于磁共振弹性成像的非均质性量化的1-正态波形分析：冻融循环和阿尔茨海默病的影响","authors":"Harish Palnitkar , Rolf Reiter , Shreyan Majumdar , Joseph Crutison , Shujun Lin , Thomas J. Royston , Dieter Klatt","doi":"10.1016/j.jmbbm.2024.106636","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Despite its success in the mechanical characterization of biological tissues, magnetic resonance elastography (MRE) uses ill-posed wave inversions to estimate tissue stiffness. 1-Norm has been recently introduced as a mathematical measure for the scattering of mechanical waves due to inhomogeneities based on an analysis of the delineated contours of wave displacement.</p></div><div><h3>Purpose</h3><p>To investigate 1-Norm as an MRE-based quantitative biomarker of mechanical inhomogeneities arising from microscopic structural tissue alterations caused by the freeze-thaw cycle (FTC) or Alzheimer's disease (AD).</p></div><div><h3>Methods</h3><p>In this proof-of-concept study, we prospectively investigated excised porcine kidney (<em>n</em> = 6), liver (<em>n</em> = 6), and muscle (<em>n</em> = 6) before vs. after the FTC at 500–2000 Hz and excised murine brain of healthy controls (<em>n</em> = 3) vs. 5xFAD species with AD (<em>n</em> = 3) at 1200–1800 Hz using 0.5 T tabletop MRE. 1-Norm analysis was compared with conventional wave inversion.</p></div><div><h3>Results</h3><p>While the FTC reduced both stiffness and inhomogeneity in kidney, liver, and muscle tissue, AD led to lower brain stiffness but more pronounced mechanical inhomogeneity.</p></div><div><h3>Conclusion</h3><p>Our preliminary results show that 1-Norm is sensitive to tissue mechanical inhomogeneity due to FTC and AD without relying on ill-posed wave inversion techniques. 1-Norm has the potential to be used as an MRE-based diagnostic biomarker independent of stiffness to characterize abnormal conditions that involve changes in tissue mechanical inhomogeneity.</p></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1751616124002686/pdfft?md5=47a2a48c69f7ce95b3c19f4720821a85&pid=1-s2.0-S1751616124002686-main.pdf","citationCount":"0","resultStr":"{\"title\":\"1-Norm waveform analysis for MR elastography-based quantification of inhomogeneity: Effects of the freeze-thaw cycle and Alzheimer's disease\",\"authors\":\"Harish Palnitkar , Rolf Reiter , Shreyan Majumdar , Joseph Crutison , Shujun Lin , Thomas J. Royston , Dieter Klatt\",\"doi\":\"10.1016/j.jmbbm.2024.106636\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Despite its success in the mechanical characterization of biological tissues, magnetic resonance elastography (MRE) uses ill-posed wave inversions to estimate tissue stiffness. 1-Norm has been recently introduced as a mathematical measure for the scattering of mechanical waves due to inhomogeneities based on an analysis of the delineated contours of wave displacement.</p></div><div><h3>Purpose</h3><p>To investigate 1-Norm as an MRE-based quantitative biomarker of mechanical inhomogeneities arising from microscopic structural tissue alterations caused by the freeze-thaw cycle (FTC) or Alzheimer's disease (AD).</p></div><div><h3>Methods</h3><p>In this proof-of-concept study, we prospectively investigated excised porcine kidney (<em>n</em> = 6), liver (<em>n</em> = 6), and muscle (<em>n</em> = 6) before vs. after the FTC at 500–2000 Hz and excised murine brain of healthy controls (<em>n</em> = 3) vs. 5xFAD species with AD (<em>n</em> = 3) at 1200–1800 Hz using 0.5 T tabletop MRE. 1-Norm analysis was compared with conventional wave inversion.</p></div><div><h3>Results</h3><p>While the FTC reduced both stiffness and inhomogeneity in kidney, liver, and muscle tissue, AD led to lower brain stiffness but more pronounced mechanical inhomogeneity.</p></div><div><h3>Conclusion</h3><p>Our preliminary results show that 1-Norm is sensitive to tissue mechanical inhomogeneity due to FTC and AD without relying on ill-posed wave inversion techniques. 1-Norm has the potential to be used as an MRE-based diagnostic biomarker independent of stiffness to characterize abnormal conditions that involve changes in tissue mechanical inhomogeneity.</p></div>\",\"PeriodicalId\":380,\"journal\":{\"name\":\"Journal of the Mechanical Behavior of Biomedical Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1751616124002686/pdfft?md5=47a2a48c69f7ce95b3c19f4720821a85&pid=1-s2.0-S1751616124002686-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Mechanical Behavior of Biomedical Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1751616124002686\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Mechanical Behavior of Biomedical Materials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1751616124002686","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
1-Norm waveform analysis for MR elastography-based quantification of inhomogeneity: Effects of the freeze-thaw cycle and Alzheimer's disease
Background
Despite its success in the mechanical characterization of biological tissues, magnetic resonance elastography (MRE) uses ill-posed wave inversions to estimate tissue stiffness. 1-Norm has been recently introduced as a mathematical measure for the scattering of mechanical waves due to inhomogeneities based on an analysis of the delineated contours of wave displacement.
Purpose
To investigate 1-Norm as an MRE-based quantitative biomarker of mechanical inhomogeneities arising from microscopic structural tissue alterations caused by the freeze-thaw cycle (FTC) or Alzheimer's disease (AD).
Methods
In this proof-of-concept study, we prospectively investigated excised porcine kidney (n = 6), liver (n = 6), and muscle (n = 6) before vs. after the FTC at 500–2000 Hz and excised murine brain of healthy controls (n = 3) vs. 5xFAD species with AD (n = 3) at 1200–1800 Hz using 0.5 T tabletop MRE. 1-Norm analysis was compared with conventional wave inversion.
Results
While the FTC reduced both stiffness and inhomogeneity in kidney, liver, and muscle tissue, AD led to lower brain stiffness but more pronounced mechanical inhomogeneity.
Conclusion
Our preliminary results show that 1-Norm is sensitive to tissue mechanical inhomogeneity due to FTC and AD without relying on ill-posed wave inversion techniques. 1-Norm has the potential to be used as an MRE-based diagnostic biomarker independent of stiffness to characterize abnormal conditions that involve changes in tissue mechanical inhomogeneity.
期刊介绍：
The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials.
The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.
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