益气养阴煎剂联合辅助化疗对乳腺癌术后生活质量的临床疗效

IF 2 4区 医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2024-01-01 Epub Date: 2024-06-23 DOI:10.1080/01635581.2024.2364392
Zhengju Tang, Peng Zhou, Huali Sun
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引用次数: 0

摘要

术后辅助化疗可提高乳腺癌患者的生活质量,但也会带来副作用,引起不良反应。据报道,益气养阴煎剂具有抗癌活性,已被用于各种癌症的术后治疗。本研究共纳入 128 例接受手术治疗的乳腺癌患者,并将其随机分为对照组和试验组,分别接受不同的治疗。对照组患者接受氟尿嘧啶和盐酸的单一化疗,而试验组患者的治疗则在对照组的基础上辅以益气养阴煎剂。两种治疗策略均改善了入组患者的生活质量和中医证候评分,其中辅以益气养阴煎剂的治疗效果显著。两组患者均出现了恶心、呕吐、血小板减少、腹泻、白细胞减少和血红蛋白减少等不良反应,但应用益气养阴煎剂后不良反应明显减轻。此外,试验组患者的 1 年无病生存率更高。益气养阴汤联合辅助化疗可改善乳腺癌患者的术后生活质量,提高疗效,减少不良反应。
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Clinical Efficacy of Yiqi Yangyin Decoction Combined with Adjuvant Chemotherapy on the Postoperative Life Quality of Breast Cancer.

Postoperative adjuvant chemotherapy could improve the life quality of patients with breast cancer but also bring side effects and cause adverse reactions. Yiqi Yangyin decoction has been reported to possess anti-cancer activity and has been employed in the postoperative treatment of various cancers. A total of 128 patients with breast cancer who received surgical therapy were enrolled in this study and were randomly grouped as the control and the test group to receive different therapies. Patients in the control group received single chemotherapy of fluorouracil and hydrochloride, while the therapy of the test group patients supplemented Yiqi Yangyin decoction based on the control group. Both two therapeutic strategies improved life quality and TCM syndrome scores of enrolled patients, and the supplement of Yiqi Yangyin decoction significantly improved the therapeutic effect. Adverse reactions including nausea, vomiting, thrombocytopenia, diarrhea, leukopenia, and hemoglobinia occurred in both two groups, but the application of Yiqi Yangyin decoction significantly alleviated adverse reactions. Additionally, patients in the test group showed a better 1-year disease-free survival. The combination of adjuvant chemotherapy with Yiqi Yangyin decoction could improve postoperative life quality, improve therapeutic efficacy, and reduce adverse reactions in patients with breast cancer.

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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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