熊去氧胆酸治疗对 COVID-19 自身免疫性肝病患者的影响及其临床预后

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Biosafety and Health Pub Date : 2024-06-01 DOI:10.1016/j.bsheal.2024.04.004
Minghui Li , Weihua Cao , Tingting Jiang , Wen Deng , Shiyu Wang , Shuling Wu , Lu Zhang , Yao Lu , Min Chang , Ruyu Liu , Xiaoyan Ding , Ge Shen , Yuanjiao Gao , Hongxiao Hao , Xiaoxue Chen , Leiping Hu , Mengjiao Xu , Yuyong Jiang , Wei Yi , Yao Xie , Rui Song
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引用次数: 0

摘要

目的:探讨熊去氧胆酸(UDCA)对自身免疫性肝病(AILD)患者严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)感染和临床预后的影响。研究人员招募了确诊为自身免疫性肝病(AILD)的患者,并根据他们是否接受 UDCA 治疗将其分为 UDCA 组和非 UDCA 组。收集了有关 AILD 诊断、治疗、生化指标和影像学检查的相关数据。观察 AILD 患者的 SARS-CoV-2 感染率和预后。共有 1 138 名患者完成了随访。非 UDCA 组用于治疗 AILD 的激素(P = 0.003)和免疫抑制剂(P = 0.001)的使用率明显低于 UDCA 组。感染 SARS-CoV-2 的患者使用 UDCA 的比例明显低于未感染患者(P = 0.003)。非 UDCA 组的 SARS-CoV-2 感染率明显高于 UDCA 组(P = 0.018)。逻辑回归分析显示,使用 UDCA(P = 0.003)与较低的 SARS-CoV-2 感染率相关,而使用免疫抑制剂(P = 0.017)则会增加感染率。接受 UDCA 治疗的患者从 SARS-CoV-2 感染中恢复的时间明显长于未接受 UDCA 治疗的患者(P = 0.018)。UDCA 可降低 AILD 患者的 SARS-CoV-2 感染率,而免疫抑制剂反而会增加感染率。接受 UDCA 治疗的患者在感染后的恢复时间更长。
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Impact of ursodeoxycholic acid therapy in autoimmune liver disease patients with COVID-19 and its clinical prognosis

To explore the impact of ursodeoxycholic acid (UDCA) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and clinical outcomes in patients with autoimmune liver disease (AILD). Patients diagnosed with AILD were enrolled and divided into a UDCA group and a non-UDCA group based on whether they received UDCA treatment. Relevant data were collected regarding AILD diagnosis, treatment, biochemical indicators, and imaging examination. The incidence of SARS-CoV-2 infection and the prognosis of AILD patients were observed. A total of 1,138 patients completed follow-up. The usage rate of hormone (P = 0.003) and immunosuppressant (P = 0.001) used for treating AILD in the non-UDCA group was markedly lower than in the UDCA group. The UDCA usage rate was markedly lower in SARS-CoV-2 infected patients than in uninfected patients (P = 0.003). The rate of SARS-CoV-2 infection in the non-UDCA group was significantly higher than in the UDCA group (P = 0.018). Logistic regression analysis showed that UDCA use (P = 0.003) was correlated to a lower incidence of SARS-CoV-2, while immunosuppressant use (P = 0.017) increased the incidence. Recovery time from SARS-CoV-2 infection was markedly longer for those receiving UDCA treatment than those in the non-UDCA group (P = 0.018). UDCA is associated with low SARS-CoV-2 incidence in AILD patients, while immunosuppressant increases its incidence instead. Patients receiving UDCA treatment have a longer recovery time after being infected.

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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
期刊最新文献
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