减肥手术后疱疹抑制失控。

IF 1.4 4区 医学 Q4 IMMUNOLOGY International Journal of STD & AIDS Pub Date : 2024-06-25 DOI:10.1177/09564624241264584
Shyam Samraj, Kimberley Olasoji, Raj Patel
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引用次数: 0

摘要

我们报告了一名 42 岁女性复发性生殖器疱疹(HSV-2)患者的病例,她在接受阿昔洛韦 400 毫克、每天两次的抑制性抗病毒治疗后,疱疹得到了很好的控制。患者需要进行减肥手术,以控制被认为是危险的高体重指数。然而,尽管阿昔洛韦的总剂量和频率从每天两次增加到每天三次,疱疹抑制在术后仍然无效,并出现了严重的疱疹相关并发症。在改用伐昔洛韦 500 毫克,每天两次的治疗后,疱疹得到了完全控制。Roux-en-Y 手术是最常见的减肥手术。根据对不同疱疹抗病毒药物的特性和吸收部位的了解,可以预测这些药物的疗效。在术前预期改变治疗方法可以避免类似的疱疹病毒抑制问题。
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Loss of control of herpes suppression following bariatric surgery.

We report a 42-year-old female with confirmed recurrent genital herpes (HSV-2), which was well controlled on suppressive antiviral therapy with aciclovir 400 mg twice daily. The patient required bariatric surgery in order to manage what was deemed a dangerously high BMI. A Roux-en-Y procedure was performed which effectively reduced her weight; however, herpes suppression become ineffective post operatively, with serious herpes related complications, despite increasing the total dose of aciclovir and the frequency from twice daily to three times a day. Complete herpes control was restored by changing therapy to valaciclovir 500 mg twice daily. The Roux-en-Y procedure is the most common form of bariatric surgery. Consequences on the efficacy of different herpes antivirals can be predicted from what is known of their properties and sites of absorption. Similar problems with herpes virus suppression may be avoided by an anticipated change in therapy preoperatively.

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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
144
审稿时长
3-6 weeks
期刊介绍: The International Journal of STD & AIDS provides a clinically oriented forum for investigating and treating sexually transmissible infections, HIV and AIDS. Publishing original research and practical papers, the journal contains in-depth review articles, short papers, case reports, audit reports, CPD papers and a lively correspondence column. This journal is a member of the Committee on Publication Ethics (COPE).
期刊最新文献
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