治疗皮肤病的局部应用疗法:过去、现在和未来。

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological Reviews Pub Date : 2024-08-15 DOI:10.1124/pharmrev.123.000549
Marc Brown, Adrian Williams, Robert P Chilcott, Brendan Brady, Jon Lenn, Charles Evans, Lynn Allen, William J McAuley, Mubinah Beebeejaun, Jasmin Haslinger, Claire Beuttel, Raquel Vieira, Florencia Guidali, Margarida Miranda
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引用次数: 0

摘要

本综述旨在总结外用药物领域的基本生物学、药学和临床方面的知识,以帮助科学家开发新的外用药物。在简要介绍外用给药的历史之后,我们将回顾皮肤的结构和功能、药物吸收途径及其局限性。然后详细介绍了最流行的疾病和当前的外用治疗方法,其组织结构反映了自身免疫和炎症、微生物感染、皮肤癌和遗传性皮肤病等主要疾病类别。然后重点介绍了外用产品从开发到大规模生产的复杂性,以及建议的风险缓解方法。最后讨论了这一给药领域的未来,重点是那些更有可能在目前使用的外用药物基础上取得重大改进的领域,或者那些将扩大可通过这一给药途径治疗的药物和疾病范围的领域。意义声明 对皮肤、相关疾病和当前治疗方法的主要方面以及外用制剂开发的复杂性进行综述,有助于就开发新的或改良的外用药物做出明智的决定。这些方面包括活性成分的选择、配方、目标患者群体的偏好和局限性,以及新皮肤病和外用药物方法的未来。
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Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future.

The purpose of this review is to summarize essential biological, pharmaceutical, and clinical aspects in the field of topically applied medicines that may help scientists when trying to develop new topical medicines. After a brief history of topical drug delivery, a review of the structure and function of the skin and routes of drug absorption and their limitations is provided. The most prevalent diseases and current topical treatment approaches are then detailed, the organization of which reflects the key disease categories of autoimmune and inflammatory diseases, microbial infections, skin cancers, and genetic skin diseases. The complexity of topical product development through to large-scale manufacturing along with recommended risk mitigation approaches are then highlighted. As such topical treatments are applied externally, patient preferences along with the challenges they invoke are then described, and finally the future of this field of drug delivery is discussed, with an emphasis on areas that are more likely to yield significant improvements over the topical medicines in current use or would expand the range of medicines and diseases treatable by this route of administration. SIGNIFICANCE STATEMENT: This review of the key aspects of the skin and its associated diseases and current treatments along with the intricacies of topical formulation development should be helpful in making judicious decisions about the development of new or improved topical medicines. These aspects include the choices of the active ingredients, formulations, the target patient population's preferences, limitations, and the future with regard to new skin diseases and topical medicine approaches.

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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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