腺相关病毒 2 与腺病毒 18 或疱疹病毒共存可能与免疫力低下者的严重舌乳头状瘤病有关。

IF 5.5 3区 医学 Q1 Medicine Virologica Sinica Pub Date : 2024-08-01 DOI:10.1016/j.virs.2024.06.006
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引用次数: 0

摘要

下一代测序(NGS)大大提高了各种疾病病原体诊断的准确性和效率。本研究对一名患有严重舌乳头状瘤病的 13 岁造血干细胞移植(HSCT)受者的粪便和组织样本进行了病毒元组学分析。分析结果显示,腺相关病毒2(AAV2)以及潜在辅助病毒、疱疹病毒1型(HSV-1)和不常见的腺病毒18血清型(AdV18)大量存在。虽然没有明确确定直接的因果关系,但这些病毒的同时存在表明,免疫力低下的人患上严重舌乳头瘤病可能与这些病毒有关。值得注意的是,该研究获得了 AdV18 的完整基因组序列,为了解腺病毒的遗传变异、起源和致病性提供了线索。值得注意的发现包括聚合酶中的三个氨基酸替代和六聚子中的一个氨基酸替代,这使它们与以前发表的 AdV18 株系区分开来。系统进化分析表明,我们的研究中 AdV18 的聚合酶和 hexon 区域与之前报道的 AdV18 序列之间存在密切关系。这项研究强调了全面病毒检查在阐明患有舌乳头状瘤病的造血干细胞移植患者感染情况中的关键作用。
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Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual
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来源期刊
Virologica Sinica
Virologica Sinica Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
7.70
自引率
1.80%
发文量
3149
期刊介绍: Virologica Sinica is an international journal which aims at presenting the cutting-edge research on viruses all over the world. The journal publishes peer-reviewed original research articles, reviews, and letters to the editor, to encompass the latest developments in all branches of virology, including research on animal, plant and microbe viruses. The journal welcomes articles on virus discovery and characterization, viral epidemiology, viral pathogenesis, virus-host interaction, vaccine development, antiviral agents and therapies, and virus related bio-techniques. Virologica Sinica, the official journal of Chinese Society for Microbiology, will serve as a platform for the communication and exchange of academic information and ideas in an international context. Electronic ISSN: 1995-820X; Print ISSN: 1674-0769
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