螺旋体感染会诱导不同的 CD101hi 肺组织浸润性嗜酸性粒细胞亚群,这些亚群受 2 型细胞因子的不同调节。

IF 3.2 4区 医学 Q3 CELL BIOLOGY Immunology & Cell Biology Pub Date : 2024-06-26 DOI:10.1111/imcb.12796
Sophia-Louise Noble, Francesco Vacca, Kerry L Hilligan, Thomas C Mules, Graham Le Gros, Stephen Inns
{"title":"螺旋体感染会诱导不同的 CD101hi 肺组织浸润性嗜酸性粒细胞亚群,这些亚群受 2 型细胞因子的不同调节。","authors":"Sophia-Louise Noble,&nbsp;Francesco Vacca,&nbsp;Kerry L Hilligan,&nbsp;Thomas C Mules,&nbsp;Graham Le Gros,&nbsp;Stephen Inns","doi":"10.1111/imcb.12796","DOIUrl":null,"url":null,"abstract":"<p>Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory and proinflammatory responses. Helminth infection is strongly associated with eosinophilia and the induction of the type 2 cytokines interleukin (IL)-5, IL-4 and IL-13. This study aimed to elucidate the heterogeneity of pulmonary eosinophils in response to helminth infection and the roles of IL-5, IL-4 and IL-13 in driving pulmonary eosinophil responses. Using the murine helminth model <i>Nippostrongylus brasiliensis</i> (<i>Nb</i>), we characterize a subtype of eosinophils, defined by high expression of CD101, that is induced in the lungs of <i>Nb</i>-infected mice and are phenotypically distinct from lung eosinophils that express low levels of CD101. Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization within the lung: CD101<sup>low</sup> eosinophils are predominantly localized in the lung vasculature, whereas <i>Nb</i>-induced CD101<sup>hi</sup> eosinophils are predominantly localized in the extravascular lung niche. We show that CD101<sup>hi</sup> eosinophils are also induced across other models of pulmonary infection and inflammation, including a nonlung-migrating helminth infection, house dust mite–induced allergic inflammation and influenza infection. Furthermore, we demonstrate that the induction of CD101<sup>hi</sup> tissue eosinophils is independent of IL-5 and IL-4 signaling, but is dependent on intact IL-13 signaling. These results suggest that IL-13 produced during helminth infection and other disease states promotes a pulmonary tissue-infiltrating program in eosinophils defined by high expression of CD101.</p>","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12796","citationCount":"0","resultStr":"{\"title\":\"Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines\",\"authors\":\"Sophia-Louise Noble,&nbsp;Francesco Vacca,&nbsp;Kerry L Hilligan,&nbsp;Thomas C Mules,&nbsp;Graham Le Gros,&nbsp;Stephen Inns\",\"doi\":\"10.1111/imcb.12796\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory and proinflammatory responses. Helminth infection is strongly associated with eosinophilia and the induction of the type 2 cytokines interleukin (IL)-5, IL-4 and IL-13. This study aimed to elucidate the heterogeneity of pulmonary eosinophils in response to helminth infection and the roles of IL-5, IL-4 and IL-13 in driving pulmonary eosinophil responses. Using the murine helminth model <i>Nippostrongylus brasiliensis</i> (<i>Nb</i>), we characterize a subtype of eosinophils, defined by high expression of CD101, that is induced in the lungs of <i>Nb</i>-infected mice and are phenotypically distinct from lung eosinophils that express low levels of CD101. Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization within the lung: CD101<sup>low</sup> eosinophils are predominantly localized in the lung vasculature, whereas <i>Nb</i>-induced CD101<sup>hi</sup> eosinophils are predominantly localized in the extravascular lung niche. We show that CD101<sup>hi</sup> eosinophils are also induced across other models of pulmonary infection and inflammation, including a nonlung-migrating helminth infection, house dust mite–induced allergic inflammation and influenza infection. Furthermore, we demonstrate that the induction of CD101<sup>hi</sup> tissue eosinophils is independent of IL-5 and IL-4 signaling, but is dependent on intact IL-13 signaling. These results suggest that IL-13 produced during helminth infection and other disease states promotes a pulmonary tissue-infiltrating program in eosinophils defined by high expression of CD101.</p>\",\"PeriodicalId\":179,\"journal\":{\"name\":\"Immunology & Cell Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12796\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunology & Cell Biology\",\"FirstCategoryId\":\"2\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/imcb.12796\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology & Cell Biology","FirstCategoryId":"2","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/imcb.12796","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

嗜酸性粒细胞在健康和疾病中发挥着不同的作用,既能促进免疫调节,也能促进炎症反应。蠕虫感染与嗜酸性粒细胞增多以及诱导白细胞介素(IL)-5、IL-4 和 IL-13 等 2 型细胞因子密切相关。本研究旨在阐明肺嗜酸性粒细胞对蠕虫感染反应的异质性,以及IL-5、IL-4和IL-13在驱动肺嗜酸性粒细胞反应中的作用。通过使用小鼠蠕虫模型巴西嗜酸性粒细胞绦虫(Nb),我们确定了嗜酸性粒细胞亚型的特征,该亚型由 CD101 的高表达所定义,可在 Nb 感染小鼠的肺部诱导,在表型上有别于低表达 CD101 的肺嗜酸性粒细胞。引人注目的是,我们发现这两种嗜酸性粒细胞亚型在肺内有不同的解剖定位:CD101low 嗜酸性粒细胞主要定位于肺血管,而 Nb 诱导的 CD101hi 嗜酸性粒细胞则主要定位于血管外肺龛。我们的研究表明,CD101hi 嗜酸性粒细胞在其他肺部感染和炎症模型中也能被诱导,包括非肺部移行蠕虫感染、屋尘螨诱导的过敏性炎症和流感感染。此外,我们还证明 CD101hi 组织嗜酸性粒细胞的诱导与 IL-5 和 IL-4 信号传导无关,但依赖于完整的 IL-13 信号传导。这些结果表明,在蠕虫感染和其他疾病状态下产生的 IL-13 促进了嗜酸性粒细胞的肺组织浸润程序,该程序由 CD101 的高表达所定义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines

Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory and proinflammatory responses. Helminth infection is strongly associated with eosinophilia and the induction of the type 2 cytokines interleukin (IL)-5, IL-4 and IL-13. This study aimed to elucidate the heterogeneity of pulmonary eosinophils in response to helminth infection and the roles of IL-5, IL-4 and IL-13 in driving pulmonary eosinophil responses. Using the murine helminth model Nippostrongylus brasiliensis (Nb), we characterize a subtype of eosinophils, defined by high expression of CD101, that is induced in the lungs of Nb-infected mice and are phenotypically distinct from lung eosinophils that express low levels of CD101. Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization within the lung: CD101low eosinophils are predominantly localized in the lung vasculature, whereas Nb-induced CD101hi eosinophils are predominantly localized in the extravascular lung niche. We show that CD101hi eosinophils are also induced across other models of pulmonary infection and inflammation, including a nonlung-migrating helminth infection, house dust mite–induced allergic inflammation and influenza infection. Furthermore, we demonstrate that the induction of CD101hi tissue eosinophils is independent of IL-5 and IL-4 signaling, but is dependent on intact IL-13 signaling. These results suggest that IL-13 produced during helminth infection and other disease states promotes a pulmonary tissue-infiltrating program in eosinophils defined by high expression of CD101.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Immunology & Cell Biology
Immunology & Cell Biology 医学-免疫学
CiteScore
7.50
自引率
2.50%
发文量
98
审稿时长
4-8 weeks
期刊介绍: The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.
期刊最新文献
Choose your own T-cell fate: creation of a narrative-based, decision-making activity to engage students in immunology. Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy. Variations in the germinal center response revealed by genetically diverse mouse strains. The evolving role of mast cells in wound healing: insights from recent research and diverse models. ADAM10 modulates the efficacy of T-cell-mediated therapy in solid tumors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1