Cited2 是胎盘发育和可塑性的关键调节因子。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY BioEssays Pub Date : 2024-06-24 DOI:10.1002/bies.202300118

Marija Kuna, Michael J. Soares

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引用次数: 0

摘要

滋养层细胞系发育和胎盘形成的生物学特征是有几种已知转录因子的参与。CBP-p300与富含Glu/Asp-羧基末端结构域2（CITED2）相互作用的转录激活因子是这些转录调节因子的核心。CITED2 是调节转录因子活性的核心调节因子，影响着胎盘的发育和对生理压力的适应。CITED2 对滋养层细胞系和胎盘的这些作用在小鼠、大鼠和人类中是一致的。因此，在小鼠和大鼠中可以有效地模拟 CITED2 在血胎胎盘中的生物学作用。在这篇综述中，我们介绍了 CITED2 在胎盘生物学中的保守作用，并讨论了如何利用 CITED2 作为一种工具来发现控制胎盘发育的调控机制的新见解。

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Cited2 is a key regulator of placental development and plasticity

The biology of trophoblast cell lineage development and placentation is characterized by the involvement of several known transcription factors. Central to the action of a subset of these transcriptional regulators is CBP-p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2). CITED2 acts as a coregulator modulating transcription factor activities and affecting placental development and adaptations to physiological stressors. These actions of CITED2 on the trophoblast cell lineage and placentation are conserved across the mouse, rat, and human. Thus, aspects of CITED2 biology in hemochorial placentation can be effectively modeled in the mouse and rat. In this review, we present information on the conserved role of CITED2 in the biology of placentation and discuss the use of CITED2 as a tool to discover new insights into regulatory mechanisms controlling placental development.

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来源期刊

BioEssays 生物-生化与分子生物学

CiteScore

7.30

自引率

2.50%

发文量

167

审稿时长

4-8 weeks

期刊介绍： molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.