预测阿特珠单抗和贝伐珠单抗对晚期肝细胞癌患者实际疗效的因素分析

IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Gut and Liver Pub Date : 2024-07-15 Epub Date: 2024-06-27 DOI:10.5009/gnl240085
Byeong Geun Song, Myung Ji Goh, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Yong-Han Paik
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引用次数: 0

摘要

背景/目的:在临床试验中,阿替珠单抗和贝伐珠单抗治疗晚期肝细胞癌(HCC)取得了良好的效果。本研究评估了阿特珠单抗和贝伐珠单抗治疗晚期肝细胞癌的实际疗效和安全性:在这项针对韩国三级癌症中心患者的回顾性研究中,从2022年5月到2023年6月,111名巴塞罗那临床肝癌B期或C期HCC患者接受了阿特珠单抗和贝伐单抗作为一线治疗。我们评估了无进展生存期(PFS)、总反应率(ORR)、疾病控制率(DCR)和不良事件:研究纳入了巴塞罗那临床肝癌C期HCC患者和Child-Pugh A级肝功能患者。中位PFS为6.5个月,ORR为27%,DCR为63%。研究发现,白蛋白-胆红素分级、年龄、免疫治疗中的C反应蛋白和α-胎儿蛋白评分、大血管侵犯、肺转移和联合放疗等因素对PFS有显著影响(结论:阿特珠单抗和贝伐珠单抗在晚期HCC治疗中显示出实际疗效,ORR和DCR与临床试验中观察到的结果一致。基于特定风险因素的PFS和ORR差异凸显了阿特珠单抗和贝伐珠单抗在晚期HCC精准医疗中的潜力。
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Analysis of Factors Predicting the Real-World Efficacy of Atezolizumab and Bevacizumab in Patients with Advanced Hepatocellular Carcinoma.

Background/aims: Atezolizumab and bevacizumab have shown promising results for the treatment of advanced hepatocellular carcinoma (HCC) in clinical trials. In this study, the real-world efficacy and safety of atezolizumab and bevacizumab in treating advanced HCC were evaluated.

Methods: In this retrospective study of patients at a Korean tertiary cancer center, 111 patients with Barcelona Clinic Liver Cancer stage B or C HCC received atezolizumab and bevacizumab as first-line therapy from May 2022 to June 2023. We assessed the progression-free survival (PFS), overall response rate (ORR), disease control rate (DCR), and adverse events.

Results: Patients with Barcelona Clinic Liver Cancer stage C HCC and Child-Pugh class A liver function were included in the study. The median PFS was 6.5 months, with an ORR of 27% and a DCR of 63%. Several factors, including the albumin-bilirubin grade, age, C-reactive protein and α-fetoprotein in immunotherapy score, macrovascular invasion, lung metastases, and combined radiotherapy, were found to significantly influence PFS (p<0.05). Patients with peritoneal seeding showed an higher ORR. The safety profile was consistent with that observed in clinical trials.

Conclusions: Atezolizumab and bevacizumab demonstrated real-world efficacy in the treatment of advanced HCC, with ORRs and DCRs aligning with those observed in clinical trials. Variations in PFS and ORR based on specific risk factors highlight the potential of atezolizumab and bevacizumab in precision medicine for advanced HCC.

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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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