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引用次数: 0
摘要
间歇性禁食(IF)指的是周期性禁食,即不是通过减少饭量,而是通过间歇性地不吃一顿或连续几顿饭来最大限度地减少热量摄入。间歇性禁食可促使能量代谢发生全面、多方面的改变,这些代谢通道可能充当与免疫系统对接的原始机制,促使免疫系统发生复杂的转变。这篇综述全面介绍了 IF,尤其关注它对免疫系统的影响,从而试图在这两个研究领域架起一座桥梁。我们探讨了 IF 如何影响脂质代谢、激素水平、昼夜节律、自噬、氧化应激、肠道微生物群和肠屏障完整性,并对这些因素与免疫系统之间的交叉机制进行了猜想。此外,该综述还包括有关中频对免疫系统和自身免疫性疾病患者的影响的研究成果。
A detective story of intermittent fasting effect on immunity
Intermittent fasting (IF) refers to periodic fasting routines, that caloric intake is minimized not by meal portion size reduction but by intermittently eliminating ingestion of one or several consecutive meals. IF can instigate comprehensive and multifaceted alterations in energy metabolism, these metabolic channels may aboundingly function as primordial mechanisms that interface with the immune system, instigating intricate immune transformations. This review delivers a comprehensive understanding of IF, paying particular attention to its influence on the immune system, thus seeking to bridge these two research domains. We explore how IF effects lipid metabolism, hormonal levels, circadian rhythm, autophagy, oxidative stress, gut microbiota, and intestinal barrier integrity, and conjecture about the mechanisms orchestrating the intersect between these factors and the immune system. Moreover, the review includes research findings on the implications of IF on the immune system and patients burdened with autoimmune diseases.
期刊介绍:
Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers.
Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology.
The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.