{"title":"从Paederia scandens叶子中提取的具有细胞毒性的鸢尾甙。","authors":"","doi":"10.1080/10286020.2024.2358820","DOIUrl":null,"url":null,"abstract":"<div><p>A phytochemical investigation on the 80% EtOH extract of the leaves of <em>Paederia scandens</em> (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10-<em>O</em>-<em>trans</em>-<em>p</em>-coumaroyl-(4<em>R</em>,6<em>R</em>)-3,4-dihydro-3<em>α</em>-methylthiopaederoside (<strong>1</strong>), 10-<em>O</em>-<em>trans</em>-feruloyl-(4<em>S</em>,6<em>R</em>)-3,4-dihydro-2′-<em>O</em>-3<em>α</em>-paederoside (<strong>2</strong>), and 10-<em>O</em>-<em>trans</em>-caffeoyl-paederosidic acid ethyl ester (<strong>3</strong>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested <em>in vitro</em> for cytotoxic activity against five endocrine tumor cell lines. As a result, compound <strong>1</strong> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cytotoxic iridoid glycosides from the leaves of Paederia scandens\",\"authors\":\"\",\"doi\":\"10.1080/10286020.2024.2358820\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A phytochemical investigation on the 80% EtOH extract of the leaves of <em>Paederia scandens</em> (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10-<em>O</em>-<em>trans</em>-<em>p</em>-coumaroyl-(4<em>R</em>,6<em>R</em>)-3,4-dihydro-3<em>α</em>-methylthiopaederoside (<strong>1</strong>), 10-<em>O</em>-<em>trans</em>-feruloyl-(4<em>S</em>,6<em>R</em>)-3,4-dihydro-2′-<em>O</em>-3<em>α</em>-paederoside (<strong>2</strong>), and 10-<em>O</em>-<em>trans</em>-caffeoyl-paederosidic acid ethyl ester (<strong>3</strong>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested <em>in vitro</em> for cytotoxic activity against five endocrine tumor cell lines. As a result, compound <strong>1</strong> exhibited some cytotoxicities against all the tested tumor cell lines with IC<sub>50</sub> value less than 20.0 μM.</p></div>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1028602024000948\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602024000948","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Cytotoxic iridoid glycosides from the leaves of Paederia scandens
A phytochemical investigation on the 80% EtOH extract of the leaves of Paederia scandens (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10-O-trans-p-coumaroyl-(4R,6R)-3,4-dihydro-3α-methylthiopaederoside (1), 10-O-trans-feruloyl-(4S,6R)-3,4-dihydro-2′-O-3α-paederoside (2), and 10-O-trans-caffeoyl-paederosidic acid ethyl ester (3). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against five endocrine tumor cell lines. As a result, compound 1 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 20.0 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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