N-甲基-d-天门冬氨酸受体拮抗剂对听觉刺激过程中伽马波段活动的影响与精神分裂症和早期精神病的脑电数据比较:系统回顾与展望》。

IF 5.3 1区 医学 Q1 PSYCHIATRY Schizophrenia Bulletin Pub Date : 2024-08-27 DOI:10.1093/schbul/sbae090
Bianca Bianciardi, Helena Mastek, Michelle Franka, Peter J Uhlhaas
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引用次数: 0

摘要

背景与假设:N-甲基-d-天冬氨酸受体(NMDA-R)功能低下被认为与精神分裂症(ScZ)的回路功能障碍有关。然而,NMDA-R拮抗剂用药后观察到的生理变化是否与ScZ中依赖于NMDA-R活性的听觉伽玛波段活动一致,仍有待确定:本系统综述调查了临床前研究(n = 15)和人体研究(n = 3)中 NMDA-R 拮抗剂对听觉伽玛波段活动的影响,并将这些数据与 ScZ 患者(n = 37)的脑电/脑磁图测量结果和 9 项早期精神病研究结果进行了比较。研究考察了以下伽玛波段参数:(1)诱发频谱功率,(2)审间相干性(ITPC),(3)诱导频谱功率,以及(4)基线功率:研究结果:动物和人体药理学数据显示,服用 NMDA-R 拮抗剂后,γ 波段活动降低,特别是诱发γ 波段功率和 ITPC,同时γ 波段活动增加,且呈双相效应。此外,在临床前研究中,NMDA-R 拮抗剂还能增加基线伽玛波段活性。ITPC和诱发伽玛波段功率的降低与在ScZ和早期精神病患者身上观察到的结果基本一致,大多数研究都观察到伽玛波段频谱功率和ITPC的降低。关于基线伽玛波段功率,研究结果并不一致。最后,在调查ScZ患者听觉伽玛波段活动的研究中发现了发表偏倚:我们的系统综述表明,NMDA-R拮抗剂可部分重现ScZ患者在听觉刺激过程中伽马波段频谱功率和ITPC的降低。这些研究结果将在当前涉及E/I平衡改变和NMDA功能减退在ScZ病理生理学中的作用的理论背景下进行讨论。
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Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.

Background and hypothesis: N-Methyl-d-aspartate receptor (NMDA-R) hypofunctioning has been hypothesized to be involved in circuit dysfunctions in schizophrenia (ScZ). Yet, it remains to be determined whether the physiological changes observed following NMDA-R antagonist administration are consistent with auditory gamma-band activity in ScZ which is dependent on NMDA-R activity.

Study design: This systematic review investigated the effects of NMDA-R antagonists on auditory gamma-band activity in preclinical (n = 15) and human (n = 3) studies and compared these data to electro/magneto-encephalographic measurements in ScZ patients (n = 37) and 9 studies in early-stage psychosis. The following gamma-band parameters were examined: (1) evoked spectral power, (2) intertrial phase coherence (ITPC), (3) induced spectral power, and (4) baseline power.

Study results: Animal and human pharmacological data reported a reduction, especially for evoked gamma-band power and ITPC, as well as an increase and biphasic effects of gamma-band activity following NMDA-R antagonist administration. In addition, NMDA-R antagonists increased baseline gamma-band activity in preclinical studies. Reductions in ITPC and evoked gamma-band power were broadly compatible with findings observed in ScZ and early-stage psychosis patients where the majority of studies observed decreased gamma-band spectral power and ITPC. In regard to baseline gamma-band power, there were inconsistent findings. Finally, a publication bias was observed in studies investigating auditory gamma-band activity in ScZ patients.

Conclusions: Our systematic review indicates that NMDA-R antagonists may partially recreate reductions in gamma-band spectral power and ITPC during auditory stimulation in ScZ. These findings are discussed in the context of current theories involving alteration in E/I balance and the role of NMDA hypofunction in the pathophysiology of ScZ.

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来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
期刊最新文献
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