在COVID-19相关嗅觉损伤时代，感染后嗅觉功能障碍患者的副嗅症。

IF 0.8 4区医学 Q4 OTORHINOLARYNGOLOGY Hno Pub Date : 2024-09-01 Epub Date: 2024-06-27 DOI:10.1007/s00106-024-01470-7

Nadine Gunder, Thomas Hummel

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引用次数: 0

摘要

目的：大量嗅觉障碍患者受到副嗅症或幻嗅症的影响。本研究旨在探讨嗅觉障碍的人口统计学和临床特征：我们对在嗅觉和味觉门诊就诊的患者进行了回顾性数据分析。共纳入 297 名患者（203 名女性，平均年龄（44.4 ± 13.7）岁）。嗅觉功能采用 "Sniffin' Sticks "综合 TDI（气味阈值、确定和识别）评分进行量化。通过病史和嗅觉障碍调查问卷评估是否存在定性嗅觉障碍：结果：大多数患者在感染 SARS-CoV-2 后出现嗅觉障碍（84%），并被诊断为嗅隘症（49%）。与无嗅觉障碍组（n=92）相比，有嗅觉障碍患者（PAR）（n=201）明显更年轻（PAR 43.2 ± 13 岁 vs. noPAR 47 ± 15.1 岁，p = 0.03），病程稍短，但无统计学意义（PAR 10.3 ± 4.9 个月，noPAR 13.6 ± 37.6 个月，p = 0.23）。他们的 TDI 评分也更高（PAR 24.3 ± 7 分，noPAR 21.4 ± 8.2 分，p = 0.003）：结论：与无副嗅症患者相比，副嗅症患者更年轻，嗅觉功能更好。

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Parosmia in patients with post-infectious olfactory dysfunction in the era of COVID-19-associated olfactory impairment.

Objectives: A large number of patients with olfactory impairment are affected by parosmia or phantosmia. This study aimed to examine the demographic and clinical characteristics of parosmia.

Methods: We performed a retrospective data analysis of patients consulting at our Smell and Taste Outpatient Clinic. A total of 297 patients were included (203 women, mean age 44.4 ± 13.7 years). Olfactory function was quantified using the "Sniffin' Sticks" composite TDI (odor threshold, determination, and identification) score. The presence of qualitative olfactory impairment was assessed trough medical history and a parosmia questionnaire.

Results: Most of the patients showed olfactory impairment after an infection with SARS-CoV‑2 (84%) and were diagnosed with parosmia (49%). Patients with parosmia (PAR) (n = 201) were significantly younger compared to the group without parosmia (noPAR; n = 92) (PAR 43.2 ± 13 years vs. noPAR 47 ± 15.1 years, p = 0.03) and had a slightly shorter duration of disease, without reaching statistical significance (PAR 10.3 ± 4.9 months, noPAR 13.6 ± 37.6 months, p = 0.23). They also had higher TDI scores (PAR 24.3 ± 7 points, noPAR 21.4 ± 8.2 points, p = 0.003).

Conclusions: Patients affected by parosmia were younger and had a better olfactory function compared to patients without parosmia.

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来源期刊

Hno 医学-耳鼻喉科学

CiteScore

1.50

自引率

33.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： HNO is an internationally recognized journal and addresses all ENT specialists in practices and clinics dealing with all aspects of ENT medicine, e.g. prevention, diagnostic methods, complication management, modern therapy strategies and surgical procedures. Review articles provide an overview on selected topics and offer the reader a summary of current findings from all fields of ENT medicine. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.

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