成纤维细胞:自身免疫性和炎症性皮肤病治疗的新靶点。

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2024-06-01 Epub Date: 2024-06-28 DOI:10.1007/s12016-024-08997-1
Xiaoyun Chen, Yutong Wu, Sujie Jia, Ming Zhao
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引用次数: 0

摘要

成纤维细胞是皮肤结构的重要组成部分。传统观点认为,成纤维细胞通过产生细胞外基质和其他元素来维持皮肤结构。最近的研究表明,成纤维细胞可对外界刺激做出反应,并表现出多种功能,如分泌促炎因子、脂肪生成和抗原呈递,表现出显著的异质性和可塑性。这一发现将成纤维细胞定位为皮肤疾病发病机制的积极贡献者,挑战了将成纤维细胞仅视为结构实体的传统观点。根据其不同的功能,成纤维细胞可分为六种亚型:促炎症成纤维细胞、肌成纤维细胞、脂肪形成成纤维细胞、血管形成成纤维细胞、间充质成纤维细胞和抗原递呈成纤维细胞。细胞因子、新陈代谢和表观遗传学调节成纤维细胞的功能异常。成纤维细胞在不同疾病和疾病状态下表现出的动态变化值得进行全面讨论。我们重点研究了真皮成纤维细胞在炎症性和自身免疫性皮肤病(包括银屑病、白癜风、红斑狼疮、硬皮病和特应性皮炎)中的异常表现和关键作用,并提出将针对异常活化的成纤维细胞作为炎症性和自身免疫性皮肤病的潜在治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics.

Fibroblasts are crucial components of the skin structure. They were traditionally believed to maintain the skin's structure by producing extracellular matrix and other elements. Recent research illuminated that fibroblasts can respond to external stimuli and exhibit diverse functions, such as the secretion of pro-inflammatory factors, adipogenesis, and antigen presentation, exhibiting remarkable heterogeneity and plasticity. This revelation positions fibroblasts as active contributors to the pathogenesis of skin diseases, challenging the traditional perspective that views fibroblasts solely as structural entities. Based on their diverse functions, fibroblasts can be categorized into six subtypes: pro-inflammatory fibroblasts, myofibroblasts, adipogenic fibroblasts, angiogenic fibroblasts, mesenchymal fibroblasts, and antigen-presenting fibroblasts. Cytokines, metabolism, and epigenetics regulate functional abnormalities in fibroblasts. The dynamic changes fibroblasts exhibit in different diseases and disease states warrant a comprehensive discussion. We focus on dermal fibroblasts' aberrant manifestations and pivotal roles in inflammatory and autoimmune skin diseases, including psoriasis, vitiligo, lupus erythematosus, scleroderma, and atopic dermatitis, and propose targeting aberrantly activated fibroblasts as a potential therapeutic strategy for inflammatory and autoimmune skin diseases.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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