限制含硫氨基酸的摄入可通过肠道-肝脏轴逆转过量脱硫弧菌引起的肝损伤。

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-06-27 DOI:10.1080/19490976.2024.2370634
Lingxi Zhou, Gexue Lu, Yawen Nie, Yilin Ren, Jin-Song Shi, Yuzheng Xue, Zheng-Hong Xu, Yan Geng
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引用次数: 0

摘要

饮食是肠道-肝脏轴的关键因素。然而,不同饮食模式对肠道微生物群和肝功能的影响仍不清楚。在这里,我们使用啮齿动物标准饲料和纯化饮食来模拟两种常见的人类饮食模式:分别以谷物和植物为基础的饮食和以精制食品为基础的饮食,并探讨它们对肠道微生物群和肝脏的影响。用纯化饮食喂养的小鼠肠道微生物群发生了很大变化,脱硫弧菌明显增加,肠道胆汁酸(BA)水平显著升高,肝脏也出现了炎症。在摄入脱硫弧菌 ATCC 29,577 (DSV) 后,以清淡饮食喂养的小鼠也出现了肝脏炎症和肠道 BA 水平升高。限制含硫氨基酸(SAA)的摄入主要是通过提高肝脏的抗氧化和解毒能力来防止肝脏损伤,并逆转过量脱硫弧菌导致的BA水平升高。人类粪便微生物群与初级 BAs 的体内外发酵表明,DSV 可促进次级 BAs 的产生。无菌小鼠在接受 DSV 治疗后,其肠道中一级和二级 BA 的浓度均有所提高。总之,限制饮食中的SAAs可能会成为一种有效的饮食干预措施,以防止肠道中过多的脱硫弧菌对肝脏造成损伤。
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Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut-liver axis.

Diet is a key player in gut-liver axis. However, the effect of different dietary patterns on gut microbiota and liver functions remains unclear. Here, we used rodent standard chow and purified diet to mimic two common human dietary patterns: grain and plant-based diet and refined-food-based diet, respectively and explored their impacts on gut microbiota and liver. Gut microbiota experienced a great shift with notable increase in Desulfovibrio, gut bile acid (BA) levels elevated significantly, and liver inflammation was observed in mice fed with the purified diet. Liver inflammation and elevated gut BA levels also occurred in mice fed with the chow diet after receiving Desulfovibrio desulfuricans ATCC 29,577 (DSV). Restriction of sulfur-containing amino acids (SAAs) prevented liver injury mainly through higher hepatic antioxidant and detoxifying ability and reversed the elevated BA levels due to excess Desulfovibrio. Ex vivo fermentation of human fecal microbiota with primary BAs demonstrated that DSV enhanced production of secondary BAs. Higher concentration of both primary and secondary BAs were found in the gut of germ-free mice after receiving DSV. In conclusion, Restriction of SAAs in diet may become an effective dietary intervention to prevent liver injury associated with excess Desulfovibrio in the gut.

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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
期刊最新文献
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