Justin Leal, Samuel S Wellman, William A Jiranek, Thorsten M Seyler, Michael P Bolognesi, Sean P Ryan
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Patients were then compared based on whether their home oral hypoglycemic regimen was continued vs discontinued in favor of initiating insulin while inpatient and analyzed using multivariable regression analysis.</p><p><strong>Results: </strong>A total of 532 patients undergoing total hip arthroplasty met inclusion criteria, with 78.6% continuing their home oral hypoglycemic regimen. Those who continued showed significantly lower median maximum inpatient blood glucose (178.5 mg/dL vs 249.5 mg/dL; <i>P</i><.001) and median average inpatient blood glucose (138.4 mg/dL vs 178.6 mg/dL; <i>P</i><.001). Linear regression analysis, adjusting for various potential confounding factors, revealed a positive correlation between discontinuation of home hypoglycemic medications and higher maximum in-patient blood glucose (β=70.15 [95% CI, 59.27-81.03]; <i>P</i><.001). Patients in the continuation group had lower proportions of acute kidney injury (18.7% vs 41.2%; <i>P</i><.001) and metabolic acidosis (4.3% vs 17.5%; <i>P</i><.001), along with a shorter length of stay (1.0 vs 2.0 days; <i>P</i><.001).</p><p><strong>Conclusion: </strong>These findings suggest that continuing a home oral hypoglycemic regimen for patients with diabetes after total hip arthroplasty is associated with superior glycemic control without exacerbating renal abnormalities or increasing metabolic complications. 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Additionally, patients whose diabetes was not managed inpatient postoperatively were excluded. Included patients were retrospectively evaluated for early postoperative glycemic control, renal function, and metabolic abnormalities. Patients were then compared based on whether their home oral hypoglycemic regimen was continued vs discontinued in favor of initiating insulin while inpatient and analyzed using multivariable regression analysis.</p><p><strong>Results: </strong>A total of 532 patients undergoing total hip arthroplasty met inclusion criteria, with 78.6% continuing their home oral hypoglycemic regimen. Those who continued showed significantly lower median maximum inpatient blood glucose (178.5 mg/dL vs 249.5 mg/dL; <i>P</i><.001) and median average inpatient blood glucose (138.4 mg/dL vs 178.6 mg/dL; <i>P</i><.001). Linear regression analysis, adjusting for various potential confounding factors, revealed a positive correlation between discontinuation of home hypoglycemic medications and higher maximum in-patient blood glucose (β=70.15 [95% CI, 59.27-81.03]; <i>P</i><.001). Patients in the continuation group had lower proportions of acute kidney injury (18.7% vs 41.2%; <i>P</i><.001) and metabolic acidosis (4.3% vs 17.5%; <i>P</i><.001), along with a shorter length of stay (1.0 vs 2.0 days; <i>P</i><.001).</p><p><strong>Conclusion: </strong>These findings suggest that continuing a home oral hypoglycemic regimen for patients with diabetes after total hip arthroplasty is associated with superior glycemic control without exacerbating renal abnormalities or increasing metabolic complications. 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引用次数: 0
摘要
背景:这项回顾性研究调查了对接受全髋关节置换术的糖尿病患者继续与停止家庭口服降糖药的影响:排除了不完全接受家庭口服降糖药治疗的患者。此外,还排除了术后未住院治疗的糖尿病患者。对纳入患者的术后早期血糖控制、肾功能和代谢异常进行回顾性评估。然后根据患者在住院期间是否继续使用家庭口服降糖药与停止使用胰岛素进行比较,并使用多变量回归分析进行分析:共有532名接受全髋关节置换术的患者符合纳入标准,其中78.6%的患者继续使用家庭口服降糖药。这些患者的住院血糖最高值中位数明显降低(178.5 mg/dL vs 249.5 mg/dL; PPPPPPC结论:这些研究结果表明,对全髋关节置换术后的糖尿病患者继续采用家庭口服降糖药治疗与良好的血糖控制有关,同时不会加剧肾功能异常或增加代谢并发症。[骨科。202x;4x(x):xx-xx]。
Continuing Home Oral Hypoglycemic Medications Was Associated With Superior Postoperative Glycemic Control Versus Initiating Sliding Scale Insulin After Total Hip Arthroplasty.
Background: This retrospective study investigated the impact of continuing vs discontinuing home oral hypoglycemic medications for patients with diabetes undergoing total hip arthroplasty.
Materials and methods: Patients who were not exclusively receiving home oral hypoglycemic regimens were excluded. Additionally, patients whose diabetes was not managed inpatient postoperatively were excluded. Included patients were retrospectively evaluated for early postoperative glycemic control, renal function, and metabolic abnormalities. Patients were then compared based on whether their home oral hypoglycemic regimen was continued vs discontinued in favor of initiating insulin while inpatient and analyzed using multivariable regression analysis.
Results: A total of 532 patients undergoing total hip arthroplasty met inclusion criteria, with 78.6% continuing their home oral hypoglycemic regimen. Those who continued showed significantly lower median maximum inpatient blood glucose (178.5 mg/dL vs 249.5 mg/dL; P<.001) and median average inpatient blood glucose (138.4 mg/dL vs 178.6 mg/dL; P<.001). Linear regression analysis, adjusting for various potential confounding factors, revealed a positive correlation between discontinuation of home hypoglycemic medications and higher maximum in-patient blood glucose (β=70.15 [95% CI, 59.27-81.03]; P<.001). Patients in the continuation group had lower proportions of acute kidney injury (18.7% vs 41.2%; P<.001) and metabolic acidosis (4.3% vs 17.5%; P<.001), along with a shorter length of stay (1.0 vs 2.0 days; P<.001).
Conclusion: These findings suggest that continuing a home oral hypoglycemic regimen for patients with diabetes after total hip arthroplasty is associated with superior glycemic control without exacerbating renal abnormalities or increasing metabolic complications. [Orthopedics. 2024;47(5):276-282.].
期刊介绍:
For over 40 years, Orthopedics, a bimonthly peer-reviewed journal, has been the preferred choice of orthopedic surgeons for clinically relevant information on all aspects of adult and pediatric orthopedic surgery and treatment. Edited by Robert D''Ambrosia, MD, Chairman of the Department of Orthopedics at the University of Colorado, Denver, and former President of the American Academy of Orthopaedic Surgeons, as well as an Editorial Board of over 100 international orthopedists, Orthopedics is the source to turn to for guidance in your practice.
The journal offers access to current articles, as well as several years of archived content. Highlights also include Blue Ribbon articles published full text in print and online, as well as Tips & Techniques posted with every issue.