肩部大手术后,过渡性疼痛管理计划可降低阿片类药物依赖性。

IF 2.9 2区 医学 Q1 ORTHOPEDICS Journal of Shoulder and Elbow Surgery Pub Date : 2025-02-01 Epub Date: 2024-06-26 DOI:10.1016/j.jse.2024.05.005
Oliver Sroka, Joseph Featherall, Kimberlee Bayless, Zachary Anderson, Adrik Da Silva, Benjamin S Brooke, Michael J Buys, Peter N Chalmers, Robert Z Tashjian
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引用次数: 0

摘要

背景:在美国,阿片类药物的过量处方增加了阿片类药物依赖、用药过量和死亡的风险。肩部骨科手术围手术期和术后阿片类药物使用量的增加是导致长期阿片类药物依赖的一个重要风险因素。作者假设,针对肩部大手术的多学科围手术期疼痛管理计划(过渡性疼痛服务或 TPS)将减少术后阿片类药物的用量:方法:退伍军人事务医疗中心实施了一项 TPS 计划,重点是非阿片类药物疼痛管理和停药支持。将实施 TPS 期间的阿片类药物消耗量与历史队列进行比较。所有接受肩关节置换术或肩袖修复术的患者都包括在内。主要结果是术后 90 天内继续使用阿片类药物的患者比例。次要结果包括术后疼痛评分、停止使用阿片类药物的时间以及 90 天内阿片类药物用量的中位数。我们建立了一个多变量模型来预测术后 90 天的阿片类药物总用量。计算了停止使用阿片类药物时间的卡普兰-梅耶曲线:结果:TPS组在出院后90天持续使用阿片类药物的情况有所减少(12.6%对28.6%;P=0.018)。与 90 天内阿片类药物总处方量增加相关的独立预测因素包括住院时间(β=19.17)、焦虑诊断(β=37.627)和出院时处方的药片数量(β=1.353)。与肩袖修复术(RCR)相比,肩关节置换术(TSA)减少了阿片类药物的90天使用量(β=-32.535)。与 RCR(8 天)相比,TSA 停止使用阿片类药物的中位时间更短(6 天)。TSA患者出院后第2天的疼痛评分低于人群平均值,RCR患者出院后第7天的疼痛评分低于人群平均值。在TPS管理下,RCR和TSA手术组出院后阿片类药片(羟考酮5毫克)的中位数均为25片(180 MME):本研究表明,与历史对照组相比,TPS可减少肩关节置换术或肩袖修复术患者在90天内的阿片类药物用量。多变量回归表明,出院时阿片类药物片剂较少是有助于减少阿片类药物用量的一个可调节因素,而焦虑诊断、住院时间延长和肩袖修复手术是与阿片类药物用量增加独立相关的其他因素。这些数据将有助于外科医生为患者提供咨询、设定麻醉剂使用预期并尽量减少过度处方。采用类似的多学科围手术期疼痛管理计划可能会大大减少全国范围内的阿片类药物超量处方。
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A transitional pain management program is associated with reduced opioid dependence after major shoulder surgery.

Background: Overprescription of opioids in the United States increases risks of opioid dependence, overdose, and death. Increased perioperative and postoperative opioid use during orthopedic shoulder surgery is a significant risk factor for long-term opioid dependence. The authors hypothesized that a multidisciplinary perioperative pain management program (Transitional Pain Service [TPS]) for major shoulder surgery would lead to a reduced amount of opioids required postoperatively.

Methods: A TPS was implemented at a Veterans Affairs Medical Center focused on nonopioid pain management and cessation support. Opioid consumption during the implementation of the TPS was compared to a historical cohort. All patients undergoing total shoulder arthroplasty (TSA) or rotator cuff repair (RCR) were included. The primary outcome was the proportion of patients continuing opioid use at 90 days postoperatively. Secondary outcomes included postoperative pain scores, time to opioid cessation, and median opioid tablets consumed at 90 days. A multivariable model was developed to predict total opioid use at 90 days postoperatively. Kaplan-Meier curves were calculated for time to opioid cessation.

Results: The TPS group demonstrated decreased persistent opioid use at 90 days postdischarge (12.6% vs. 28.6%; P = .018). Independent predictors associated with increased total opioid tablet prescriptions at 90 days included length of stay (β = 19.17), anxiety diagnosis (β = 37.627), and number of tablets prescribed at discharge (β = 1.353). TSA was associated with decreased 90-day opioid utilization (β = -32.535) when compared to RCR. Median time to cessation was shorter in TSA (6 days) when compared with RCR (8 days). Pain scores were reduced compared with population mean by postdischarge day 2 for TSA and by postdischarge day 7 for RCR. Median number of postdischarge opioid tablets (oxycodone 5 mg) consumed under TPS management was 25 in both RCR and TSA surgery groups (180 morphine milligram equivalents).

Discussion and conclusions: This study demonstrates that a TPS reduces the amount of opioid use of patients undergoing shoulder arthroplasty or cuff repair at 90 days when compared with a historical control. Multivariable regression indicated that fewer opioid tablets at discharge was a modifiable factor that may aid in reducing opioid consumption and that anxiety diagnosis, increased length of stay, and cuff repair surgery were other factors independently associated with increased opioid consumption. These data will assist surgeons in counseling patients, setting narcotic use expectations, and minimizing overprescribing. Use of a similar multidisciplinary perioperative pain management program may greatly reduce opioid overprescriptions nationally.

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来源期刊
CiteScore
6.50
自引率
23.30%
发文量
604
审稿时长
11.2 weeks
期刊介绍: The official publication for eight leading specialty organizations, this authoritative journal is the only publication to focus exclusively on medical, surgical, and physical techniques for treating injury/disease of the upper extremity, including the shoulder girdle, arm, and elbow. Clinically oriented and peer-reviewed, the Journal provides an international forum for the exchange of information on new techniques, instruments, and materials. Journal of Shoulder and Elbow Surgery features vivid photos, professional illustrations, and explicit diagrams that demonstrate surgical approaches and depict implant devices. Topics covered include fractures, dislocations, diseases and injuries of the rotator cuff, imaging techniques, arthritis, arthroscopy, arthroplasty, and rehabilitation.
期刊最新文献
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