从放射治疗计算机断层扫描中确定全景重建计算机断层扫描图像上剂量分布的新方法。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Imaging Science in Dentistry Pub Date : 2024-06-01 Epub Date: 2024-04-02 DOI:10.5624/isd.20230230
Hiroyuki Okamoto, Madoka Sakuramachi, Wakako Yatsuoka, Takao Ueno, Kouji Katsura, Naoya Murakami, Satoshi Nakamura, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Yasunori Shuto, Yuki Takano, Yuta Kobayashi, Hironori Kishida, Yuka Urago, Masato Nishitani, Shuka Nishina, Koushin Arai, Hiroshi Igaki
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引用次数: 0

摘要

目的:头颈部癌症(HNC)患者在接受放射治疗(RT)期间进行牙科手术,会增加患骨软化症(ORN)的风险。因此,必须开发新的工具来提取有关牙齿和下颌骨所受剂量的关键信息。本文提出了一种在全景重建计算机断层扫描(pCT)图像上可视化三维计划剂量分布的新方法:纳入了四名接受容积调制弧治疗的 HNC 患者。其中一名患者出现 ORN,需要在 RT 后拔牙。在研究方法中,使用开源平台定义了牙弓曲线(DAC)。随后,根据新坐标系生成 pCT 图像和剂量分布。所有牙齿和下颌骨都在原始 CT 和 pCT 图像上进行了划定。为了评估剂量指标的一致性,采用了曼-惠特尼 U 检验和学生 t 检验:结果:共评估了 61 颗牙齿和 4 个下颌骨。两种方法之间的相关系数为 0.999,没有发现统计学上的显著差异(P>0.05)。这种方法有助于直接、直观地了解放射剂量。在一名患者身上,ORN 与接受高剂量(约 70 Gy)的牙根和牙龈区域相对应:结论:建议的方法对参与 HNC 患者治疗的牙医特别有益。它能在 pCT 上显示牙齿和下颌骨的三维剂量分布,从而加深对 RT 期间所投放剂量的理解。
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A novel method for determining dose distribution on panoramic reconstruction computed tomography images from radiotherapy computed tomography.

Purpose: Patients with head and neck cancer (HNC) who undergo dental procedures during radiotherapy (RT) face an increased risk of developing osteoradionecrosis (ORN). Accordingly, new tools must be developed to extract critical information regarding the dose delivered to the teeth and mandible. This article proposes a novel approach for visualizing 3-dimensional planned dose distributions on panoramic reconstruction computed tomography (pCT) images.

Materials and methods: Four patients with HNC who underwent volumetric modulated arc therapy were included. One patient experienced ORN and required the extraction of teeth after RT. In the study approach, the dental arch curve (DAC) was defined using an open-source platform. Subsequently, pCT images and dose distributions were generated based on the new coordinate system. All teeth and mandibles were delineated on both the original CT and pCT images. To evaluate the consistency of dose metrics, the Mann-Whitney U test and Student t-test were employed.

Results: A total of 61 teeth and 4 mandibles were evaluated. The correlation coefficient between the 2 methods was 0.999, and no statistically significant difference was observed (P>0.05). This method facilitated a straightforward and intuitive understanding of the delivered dose. In 1 patient, ORN corresponded to the region of the root and the gum receiving a high dosage (approximately 70 Gy).

Conclusion: The proposed method particularly benefits dentists involved in the management of patients with HNC. It enables the visualization of a 3-dimensional dose distribution in the teeth and mandible on pCT, enhancing the understanding of the dose delivered during RT.

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来源期刊
Imaging Science in Dentistry
Imaging Science in Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
2.90
自引率
11.10%
发文量
42
期刊最新文献
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