长COVID是一种加速生物衰老的疾病：转化老年科学干预措施的机会。

IF 12.5 1区医学 Q1 CELL BIOLOGY Ageing Research Reviews Pub Date : 2024-06-28 DOI:10.1016/j.arr.2024.102400

Areez Shafqat , Mary Clare Masters , Utkarsh Tripathi , Tamara Tchkonia , James L. Kirkland , Shahrukh K. Hashmi

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引用次数: 0

摘要

长COVID--COVID-19幸存者面临的旷日持久的后果--首次被描述至今已有四年。然而，越来越多的 COVID-19 幸存者的生活质量仍然受到这种疾病的严重破坏，而且没有任何治疗方法获得批准。此外，针对这种疾病生物学根源的临床试验仍然很少。值得注意的是，长期 COVID 的症状--包括但不限于运动不耐受、认知障碍、正位和功能衰退--通常随着年龄的增长而出现。利用这种相似性，我们认为老年科学（旨在针对衰老的生物学驱动因素来预防老年相关疾病）可为长COVID提供有前景的治疗途径。有鉴于此，本综述提出了一个研究长 COVID 的框架，将其视为一种有效加速生物衰老的状态。因此，我们在此全面回顾了生物衰老标志在长 COVID 中的作用，找出了研究空白，并提出了未来临床前和临床研究的方向。

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Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

It has been four years since long COVID—the protracted consequences that survivors of COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life of an increasing number of COVID-19 survivors without any approved therapy and a paucity of clinical trials addressing its biological root causes. Notably, many of the symptoms of long COVID are typically seen with advancing age. Leveraging this similarity, we posit that Geroscience—which aims to target the biological drivers of aging to prevent age-associated conditions as a group—could offer promising therapeutic avenues for long COVID. Bearing this in mind, this review presents a translational framework for studying long COVID as a state of effectively accelerated biological aging, identifying research gaps and offering recommendations for future preclinical and clinical studies.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.