作为氯霉素抗菌生物活性增强剂的大叶黄杨果实提取物和酚类化合物

IF 3.1 2区 农林科学 Q2 CHEMISTRY, APPLIED Plant Foods for Human Nutrition Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI:10.1007/s11130-024-01206-6
Rakshandha Saini, Vikas Kumar, Anuradha Sourirajan, Kamal Dev
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引用次数: 0

摘要

传统上,人们利用大叶女贞(Emblica officinalis的同义词)的果实来增强免疫系统,抵御细菌和真菌疾病。本研究旨在评估氯霉素与从白皮冬青果实中发现的几种酚类化合物对细菌菌株的协同作用。将白皮松果实提取物及其酚类化合物与氯霉素结合使用,对革兰氏阳性菌和革兰氏阴性菌均具有协同抗菌活性。将 MICGA 与 ½MICChl 结合使用可显著提高生物活性,对枯草杆菌的活性提高了 333.33 倍。同样,MICGA 与 2MICChl 的组合对金黄色葡萄球菌的生物活性增强了 16.02 倍。同时使用 ½MICQ 和 ½MICChl 对铜绿假单胞菌的生物活性显著提高了 35.71 倍。同样,MIC GA 和 ½MICChl 的组合对大肠杆菌的生物活性显著提高了 166.66 倍。2MICFPE 和 ½MICChloramphenicol 以及 ½MICGA 和 ½MICChl 的组合对肺炎双球菌的生物活性增强了 17.85 倍。这项研究表明,可以利用大蒜的果实提取物及其酚类化合物来增强传统抗生素的效力,因为传统抗生素对细菌感染具有抗药性。
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Fruit Extract and Phenolic Compounds of Phyllanthus emblica Fruits as Bioactivity Enhancer of Chloramphenicol Against Bacterial Species.

Phyllanthus emblica L. (syn. Emblica officinalis) fruits have been traditionally exploited to enhance the immune system and provide protection against bacterial and fungal diseases. The present study aimed to evaluate the synergistic interactions between chloramphenicol and several phenolic compounds found in P. emblica fruits against bacterial strains. The combination of P. emblica fruit extracts and its phenolic compounds demonstrated synergistic antibacterial activity when used in conjunction with chloramphenicol against both Gram-positive and Gram-negative bacteria. The combination of MICGA with ½MICChl exhibited a significant increase in bioactivity, with a 333.33-fold enhancement against B. subtilis. Similarly, the combination of MICGA with 2MICChl displayed a bioactivity enhancement of 16.02 folds against S. aureus. The co-administration of ½MICQ and ½MICChl resulted in a significant 35.71-fold increase in bioactivity against P. aeruginosa. Similarly, the combination of MIC GA and ½MICChl exhibited a remarkable 166.66-fold enhancement in bioactivity against E. coli. The combinations of 2MICFPE and ½MICChloramphenicol, as well as ½MICGA and ½MICChl demonstrated the highest bioactivity enhancement of 17.85 folds for K. pneumoniae. This study claimed that the fruit extracts of P. emblica and its phenolic compounds could be utilized to augment the effectiveness of conventional antibiotics, which have acquired resistance to bacterial infections.

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来源期刊
Plant Foods for Human Nutrition
Plant Foods for Human Nutrition 工程技术-食品科技
CiteScore
6.80
自引率
7.50%
发文量
89
审稿时长
12-24 weeks
期刊介绍: Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods
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