利用原子力显微镜对慢性淋巴细胞白血病细胞的粘附力、折叠因子和表面粗糙度进行实验研究

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL Powder Technology Pub Date : 2024-06-19 DOI:10.1016/j.powtec.2024.120025

Moharram Habibnejad Korayem, Mahboube Mehrabani

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摘要

本文利用原子力显微镜（AFM）研究了慢性淋巴细胞白血病（CLL）细胞的形态学特性、接触力学、附着力、粗糙度和折叠。结果表明，CLL 细胞的形态为球形，平均表面粗糙度为 23.06 nm，褶皱率为 5.34%。CLL 细胞的粘附力和粘附功分别为 23.2 ± 15.6% nN 和 1484.6 ± 13.1% nJ。由于考虑了粘附特性，DMT 和 BCP 接触理论在表征 CLL 细胞的机械接触行为方面比赫兹理论更准确。此外，在赫兹、DMT 和 BCP 接触理论中应用折叠因子，对于相同的接触力，可预测出较大的接触半径和较小的压痕深度，其结果的准确性比光滑状态下有所提高。

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Experimental investigation of adhesion force, folding factor and surface roughness of chronic lymphocytic leukemia cell using AFM

In this paper, the Morphological properties, Contact Mechanics, Adhesion, Roughness and Folding of Chronic Lymphocytic Leukemia (CLL) cells have been examined utilizing Atomic Force Microscopy (AFM). The results show that the morphology of the CLL cell is spherical, with an average surface roughness of 23.06 nm and 5.34% folds. Adhesion force and work of adhesion of CLL cells is in the range of 23.2 ± 15.6% nN and 1484.6 ± 13.1% nJ, respectively. DMT and BCP contact theories have been more accurate than Hertz theory in characterizing the mechanical contact behavior of CLL cells due to the consideration of adhesion properties. Also, applying the folding factor in the Hertz, DMT and BCP contact theories, for the same contact force predicts a larger contact radius and a smaller indentation depth, and the accuracy of its results has increased compared to the smooth state.

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.