{"title":"产妇血小板与淋巴细胞比率、中性粒细胞与淋巴细胞比率、C 反应蛋白与分娩时胎龄和胎儿结局的相关性 - 一项来自三级医疗中心的前瞻性观察研究","authors":"Mrinalini Kannan, Sajeetha Kumari R, Vinodhini Shanmugham","doi":"10.1016/j.cegh.2024.101687","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Economic burden of preterm births can be reduced by screening and treating them at the early stage. The mechanism behind preterm birth is not clear and therefore there is no effective globally accepted treatment. Screening methods were mainly based on the previous obstetric history of the pregnant woman. Evidences indicate inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) might be potential predictors of preterm deliveries. This study was aimed to determine the relationship between preterm births and NLR, PLR and CRP levels in a singleton pregnant woman.</p></div><div><h3>Material and methods</h3><p>This prospective observational study was conducted in the Department of obstetrics and gynaecology in a tertiary care hospital located at Chengalpattu, Kanchipuram, Tamil Nadu with an objective to determine the relationship between inflammatory markers and the foetal outcome among singleton pregnant woman.The Study period was from August 2022 to July 2023 for a period of 1 year. This study enrolled pregnant women between 28 and 32 weeks of gestation attending regular antenatal clinic and those willing to give informed consent.</p></div><div><h3>Results</h3><p>There was mean difference between both the groups in terms of WBC count (white blood cell) [11.87(±3.7) in pre term vs. 10.71(±2.76) in term], platelet count [262.7(±59.1) in pre term vs. 234.5(±73.6) in term], Absolute lymphocyte count [194.0(±93.6) in preterm vs. 203.8(±63.3) in term], Neutrophil lymphocyte ratio (NLR) [6.3(±2.8) in preterm vs. 3.7(±0.8) in term] and platelet lymphocyte ratio (PLR) [165.1(±87.9) in pre term vs. 120.7± (39.1) term] and all these difference were found to be statistically significant (p-value <0.05*).</p></div><div><h3>Conclusion</h3><p>This prospective observational study deduced the association between the inflammatory markers and preterm delivery in a singleton pregnant woman. Rise in inflammatory parameters like neutrophil lymphocyte ratio, platelet lymphocyte ratio and C-reactive protein proved to be useful in predicting spontaneous preterm labour (before 37 weeks of gestation).</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424001830/pdfft?md5=71d8db29efbf5268abbbcb41746d12ae&pid=1-s2.0-S2213398424001830-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Correlation of maternal platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, C- reactive protein with gestational age at delivery and fetal outcome - A prospective observational study from tertiary care centre\",\"authors\":\"Mrinalini Kannan, Sajeetha Kumari R, Vinodhini Shanmugham\",\"doi\":\"10.1016/j.cegh.2024.101687\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Economic burden of preterm births can be reduced by screening and treating them at the early stage. The mechanism behind preterm birth is not clear and therefore there is no effective globally accepted treatment. Screening methods were mainly based on the previous obstetric history of the pregnant woman. Evidences indicate inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) might be potential predictors of preterm deliveries. This study was aimed to determine the relationship between preterm births and NLR, PLR and CRP levels in a singleton pregnant woman.</p></div><div><h3>Material and methods</h3><p>This prospective observational study was conducted in the Department of obstetrics and gynaecology in a tertiary care hospital located at Chengalpattu, Kanchipuram, Tamil Nadu with an objective to determine the relationship between inflammatory markers and the foetal outcome among singleton pregnant woman.The Study period was from August 2022 to July 2023 for a period of 1 year. This study enrolled pregnant women between 28 and 32 weeks of gestation attending regular antenatal clinic and those willing to give informed consent.</p></div><div><h3>Results</h3><p>There was mean difference between both the groups in terms of WBC count (white blood cell) [11.87(±3.7) in pre term vs. 10.71(±2.76) in term], platelet count [262.7(±59.1) in pre term vs. 234.5(±73.6) in term], Absolute lymphocyte count [194.0(±93.6) in preterm vs. 203.8(±63.3) in term], Neutrophil lymphocyte ratio (NLR) [6.3(±2.8) in preterm vs. 3.7(±0.8) in term] and platelet lymphocyte ratio (PLR) [165.1(±87.9) in pre term vs. 120.7± (39.1) term] and all these difference were found to be statistically significant (p-value <0.05*).</p></div><div><h3>Conclusion</h3><p>This prospective observational study deduced the association between the inflammatory markers and preterm delivery in a singleton pregnant woman. Rise in inflammatory parameters like neutrophil lymphocyte ratio, platelet lymphocyte ratio and C-reactive protein proved to be useful in predicting spontaneous preterm labour (before 37 weeks of gestation).</p></div>\",\"PeriodicalId\":46404,\"journal\":{\"name\":\"Clinical Epidemiology and Global Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213398424001830/pdfft?md5=71d8db29efbf5268abbbcb41746d12ae&pid=1-s2.0-S2213398424001830-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Epidemiology and Global Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213398424001830\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Epidemiology and Global Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213398424001830","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Correlation of maternal platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, C- reactive protein with gestational age at delivery and fetal outcome - A prospective observational study from tertiary care centre
Background
Economic burden of preterm births can be reduced by screening and treating them at the early stage. The mechanism behind preterm birth is not clear and therefore there is no effective globally accepted treatment. Screening methods were mainly based on the previous obstetric history of the pregnant woman. Evidences indicate inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) might be potential predictors of preterm deliveries. This study was aimed to determine the relationship between preterm births and NLR, PLR and CRP levels in a singleton pregnant woman.
Material and methods
This prospective observational study was conducted in the Department of obstetrics and gynaecology in a tertiary care hospital located at Chengalpattu, Kanchipuram, Tamil Nadu with an objective to determine the relationship between inflammatory markers and the foetal outcome among singleton pregnant woman.The Study period was from August 2022 to July 2023 for a period of 1 year. This study enrolled pregnant women between 28 and 32 weeks of gestation attending regular antenatal clinic and those willing to give informed consent.
Results
There was mean difference between both the groups in terms of WBC count (white blood cell) [11.87(±3.7) in pre term vs. 10.71(±2.76) in term], platelet count [262.7(±59.1) in pre term vs. 234.5(±73.6) in term], Absolute lymphocyte count [194.0(±93.6) in preterm vs. 203.8(±63.3) in term], Neutrophil lymphocyte ratio (NLR) [6.3(±2.8) in preterm vs. 3.7(±0.8) in term] and platelet lymphocyte ratio (PLR) [165.1(±87.9) in pre term vs. 120.7± (39.1) term] and all these difference were found to be statistically significant (p-value <0.05*).
Conclusion
This prospective observational study deduced the association between the inflammatory markers and preterm delivery in a singleton pregnant woman. Rise in inflammatory parameters like neutrophil lymphocyte ratio, platelet lymphocyte ratio and C-reactive protein proved to be useful in predicting spontaneous preterm labour (before 37 weeks of gestation).
期刊介绍:
Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.